自噬在阿尔茨海默病发病机制中的作用及治疗策略(5)
[25] Karch CM，Jeng AT，Nowotny P，et al. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains [J]. PLoS One，2012，7(11)：e50976.
[26] Matsubara E，Soto C，Governale S，et al. Apolipoprotein J and Alzheimer's amyloid beta solubility [J]. Biochem J，1996， 316(2)：671-679.
[27] Caccamo A，Majumder S，Richardson A，et al. Molecular interplay between mammalian target of rapamycin(mTOR)，amyloid-beta，and tau：effects on cognitive impairments [J]. J Biol Chem，2010，285(17)：13107-13120.
[28] Jiang T，Yu JT，Zhu XC，et al. Temsirolimus promotes autophagic clearance of amyloid-β and provide sprotective effects in cellular and animal models of Alzheimer's disease [J]. Pharmacol Res，2014，81：54-63.
[29] Nalivaeva NN，Belyaev ND，Turner AJ. Sodium valproate：an old drug with new roles [J]. Trends Pharmacol Sci，2009，30(10)：509-514.
[30] 高文凡，陳飞虎，葛金芳，等.钙络合剂BAPTA-AM对胞外酸化诱导大鼠关节软骨细胞自噬作用的影响及其可能机制[J].中国药理学通报，2015，31(5)：655-659.
[31] Anekonda TS，Quinn JF. Calcium channel blocking as a therapeutic strategy for Alzheimer's disease：the case for isradipine [J]. Biochim Biophys Acta，2011，1812(12)：1584-1590.
[32] Gu J，Congdon EE，Sigurdsson EM. Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology [J]. J Biol Chem，2013，288(46)：33081-33095.
(收稿日期：2016-09-15 本文编辑：李亚聪), http://www.100md.com(李畅 刘明妍)
[26] Matsubara E，Soto C，Governale S，et al. Apolipoprotein J and Alzheimer's amyloid beta solubility [J]. Biochem J，1996， 316(2)：671-679.
[27] Caccamo A，Majumder S，Richardson A，et al. Molecular interplay between mammalian target of rapamycin(mTOR)，amyloid-beta，and tau：effects on cognitive impairments [J]. J Biol Chem，2010，285(17)：13107-13120.
[28] Jiang T，Yu JT，Zhu XC，et al. Temsirolimus promotes autophagic clearance of amyloid-β and provide sprotective effects in cellular and animal models of Alzheimer's disease [J]. Pharmacol Res，2014，81：54-63.
[29] Nalivaeva NN，Belyaev ND，Turner AJ. Sodium valproate：an old drug with new roles [J]. Trends Pharmacol Sci，2009，30(10)：509-514.
[30] 高文凡，陳飞虎，葛金芳，等.钙络合剂BAPTA-AM对胞外酸化诱导大鼠关节软骨细胞自噬作用的影响及其可能机制[J].中国药理学通报，2015，31(5)：655-659.
[31] Anekonda TS，Quinn JF. Calcium channel blocking as a therapeutic strategy for Alzheimer's disease：the case for isradipine [J]. Biochim Biophys Acta，2011，1812(12)：1584-1590.
[32] Gu J，Congdon EE，Sigurdsson EM. Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology [J]. J Biol Chem，2013，288(46)：33081-33095.
(收稿日期：2016-09-15 本文编辑：李亚聪), http://www.100md.com(李畅 刘明妍)