川芎嗪注射液对老年慢性阻塞性肺疾病急性加重期患者内皮功能和凝血纤溶系统的影响(1)
[摘要] 目的 探討川芎嗪注射液对老年慢性阻塞性肺疾病急性加重期(AECOPD)患者肺血管内皮功能和凝血纤溶系统的影响。 方法 选取2015年8月～2016年8月右江民族医学院附属医院收治的老年AECOPD患者共120例，采用随机数字表法将其分为观察组和对照组，每组60例。对照组给予常规治疗，观察组在对照组的基础上联合川芎嗪注射液治疗。比较两组患者治疗前后第1秒用力呼气量(FEV1)、用力肺活量(FVC)、FEV1/FVC、纤维蛋白原(FIB)、凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、内皮素-1(ET-1)及一氧化氮(NO)。 结果 治疗后，观察组FEV1、FVC、FEV1/FVC、NO较治疗前显著提高(P < 0.05)，同时PT、APTT、TT、FIB及ET-1较治疗前显著降低(P < 0.05)。对照组ET-1较治疗前显著降低(P < 0.05)，NO较治疗前显著提高(P < 0.05)，FEV1、FVC、PT、APTT、TT及FIB与治疗前比较差异无统计学意义(P > 0.05)。治疗后，观察组FEV1、FVC、FEV1/FVC及NO均显著高于对照组(P < 0.05)，PT、APTT、TT、FIB及ET-1均显著低于对照组(P < 0.05)。 结论 川芎嗪注射液可调节AECOPD所致血管内皮功能障碍及血液高凝状态，改善肺功能。
[关键词] 川芎嗪注射液；慢性阻塞性肺疾病；内皮功能；凝血；肺功能
[中图分类号] R563.05 [文献标识码] A [文章编号] 1673-7210(2017)08(a)-0113-04
[Abstract] Objective To evaluate the efficacy of Ligustrazine Injection on endothelial function， coagulation fibrinolysis system in elderly patients with acute exacerbations chronic obstructive pulmonary disease (AECOPD). Methods One hundred and twenty elderly patients were AECOPD admitted to Affiliated Hospital of Youjiang Medical University for Nationalities from August 2015 to August 2016 were selected and divided into observation group and control group by random number table method， with 60 cases in each group. The control group was treated with conventional therapy， and the observation group was treated with Ligustrazine Injection combined with conventional therapy. The forced expiratory volume in the first second (FEV1)， forced vital capacity (FVC)， FEV1/FVC， fibrinogen (FIB)， prothrombin time (PT)， thrombin time (TT)， activated partial thromboplastin time (APTT)， endothelin-1 (ET-1)and nitric oxide (NO) of the two groups before and after treatment were compared. Results After treatment， the FEV1， FVC， FEV1/FVC and NO of observation group were significantly higher than those before treatment (P < 0.05)， the PT， APTT， TT， FIB and ET-1 of observation group were significantly lower than those before treatment (P < 0.05). The ET-1 of control group was significantly lower than that before treatment (P < 0.05)， and the NO of control group was significantly higher than that before treatment (P < 0.05). The FEV1， FVC， PT， APTT， TT and FIB of control group were not significantly different compared with those before treatment (P > 0.05). After treatment， the FEV1， FVC， FEV1/FVC and NO of observation group were significantly higher than those of control group (P < 0.05)， the PT， APTT， TT， FIB and ET-1 of observation group were significantly lower than those of control group (P < 0.05). Conclusion Ligustrazine Injection can adjust the endothelial function and blood high condensation state induced by AECOPD， and improve the lung function., 百拇医药(韦枫)
[关键词] 川芎嗪注射液；慢性阻塞性肺疾病；内皮功能；凝血；肺功能
[中图分类号] R563.05 [文献标识码] A [文章编号] 1673-7210(2017)08(a)-0113-04
[Abstract] Objective To evaluate the efficacy of Ligustrazine Injection on endothelial function， coagulation fibrinolysis system in elderly patients with acute exacerbations chronic obstructive pulmonary disease (AECOPD). Methods One hundred and twenty elderly patients were AECOPD admitted to Affiliated Hospital of Youjiang Medical University for Nationalities from August 2015 to August 2016 were selected and divided into observation group and control group by random number table method， with 60 cases in each group. The control group was treated with conventional therapy， and the observation group was treated with Ligustrazine Injection combined with conventional therapy. The forced expiratory volume in the first second (FEV1)， forced vital capacity (FVC)， FEV1/FVC， fibrinogen (FIB)， prothrombin time (PT)， thrombin time (TT)， activated partial thromboplastin time (APTT)， endothelin-1 (ET-1)and nitric oxide (NO) of the two groups before and after treatment were compared. Results After treatment， the FEV1， FVC， FEV1/FVC and NO of observation group were significantly higher than those before treatment (P < 0.05)， the PT， APTT， TT， FIB and ET-1 of observation group were significantly lower than those before treatment (P < 0.05). The ET-1 of control group was significantly lower than that before treatment (P < 0.05)， and the NO of control group was significantly higher than that before treatment (P < 0.05). The FEV1， FVC， PT， APTT， TT and FIB of control group were not significantly different compared with those before treatment (P > 0.05). After treatment， the FEV1， FVC， FEV1/FVC and NO of observation group were significantly higher than those of control group (P < 0.05)， the PT， APTT， TT， FIB and ET-1 of observation group were significantly lower than those of control group (P < 0.05). Conclusion Ligustrazine Injection can adjust the endothelial function and blood high condensation state induced by AECOPD， and improve the lung function., 百拇医药(韦枫)