强力枇杷露联合西药治疗慢性支气管炎急性加重期的效果及对炎性因子、生活质量的影响(1)
[摘要] 目的 探討强力枇杷露联合西药治疗慢性支气管炎急性加重期的效果及对炎性因子及生活质量的影响。方法 选取2017年2月～2019年2月解放军联勤保障部队第九一〇医院接收的98例慢性支气管炎急性加重期患者，采用乱数表法将患者随机分为研究组和对照组，每组49例。研究组采用强力枇杷露联合西药治疗，对照组采用西药治疗。比较两组患者临床疗效、临床症状恢复时间、炎性因子、生活质量及不良反应。 结果 研究组治疗2周后的临床总有效率高于对照组，差异有统计学意义(P < 0.05)。研究组咳嗽、咳痰、发热以及肺部啰音症状消退时间均短于对照组，差异均有统计学意义(均P < 0.05)。两组患者治疗2周后血清白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)水平均较治疗前下降，且研究组低于对照组，差异均有统计学意义(均P < 0.05)。两组患者治疗2周后生理机能、躯体疼痛、生理职能、一般健康、社会功能、精力、情感职能及精神状况项目评分均较治疗前升高，且研究组高于对照组，差异均有统计学意义(均P < 0.05)。两组患者不良反应发生率比较，差异无统计学意义(P > 0.05)。 结论 强力枇杷露联合西药治疗慢性支气管炎急性加重期，疗效确切，可有效改善炎性因子水平，提高患者生活质量，且不增加不良反应发生率。
[关键词] 强力枇杷露;西药;慢性支气管炎;急性加重期;疗效;炎性因子;生活质量
[中图分类号] R562.2 [文献标识码] A [文章编号] 1673-7210(2020)02(a)-0102-04
[Abstract] Objective To investigate the effect of combination of Qiangli Loquat Dew with Western medicine on acute exacerbation of chronic bronchitis and its effect on inflammatory factors and quality of life. Methods From February 2017 to February 2019， 98 cases with acute exacerbation of chronic bronchitis received by the 910th Hospital of Joint Logistic Support Force of the Chinese People′s Liberation Army were selected. The patients were randomly divided into the study group and the control group by random numbers method， with 49 cases in each group. The study group was treated with Qiangli Loquat Dew combined with western medicine， while the control group was treated with western medicine. Clinical efficacy， recovery time of clinical symptoms， inflammatory factors， quality of life and adverse reactions of patients were compared between the two groups. Results The total effective rate of the study group after 2 weeks of treatment was higher than that of the control group， and the difference was statistically significant (P < 0.05). The remission time of cough， sputum， fever and lung ralogue symptoms in the study group was shorter than those in the control group， and the differences were statistically significant (all P < 0.05). The serum levels of interleukin-6 (IL-6)， IL-8 and tumor necrosis factor-α (TNF-α) of patients in the two groups decreased after 2 weeks of treatment compared with those before treatment， and the study group were lower than those in the control group， the differences were statistically significant (all P < 0.05). The scores of physiological function， physical pain， role physical， general health， social function， energy， emotional function and mental status of patients in the two groups after 2 weeks of treatment were all higher than those before treatment， and the scores of the study group were higher than those in the control group， the differences were statistically significant (all P < 0.05). There was no significant difference of the incidence of adverse reactions of patients between the two groups (P > 0.05). Conclusion In the treatment of acute exacerbation of chronic bronchitis with combination of Qiangli Loquat Dew and Western medicine， the curative effect is definite， the level of inflammatory factors can be effectively improved， and the quality of life of patients can be improved without increasing the incidence of adverse reactions., 百拇医药(范洪涛 黄小平 黄鑫成)
[关键词] 强力枇杷露;西药;慢性支气管炎;急性加重期;疗效;炎性因子;生活质量
[中图分类号] R562.2 [文献标识码] A [文章编号] 1673-7210(2020)02(a)-0102-04
[Abstract] Objective To investigate the effect of combination of Qiangli Loquat Dew with Western medicine on acute exacerbation of chronic bronchitis and its effect on inflammatory factors and quality of life. Methods From February 2017 to February 2019， 98 cases with acute exacerbation of chronic bronchitis received by the 910th Hospital of Joint Logistic Support Force of the Chinese People′s Liberation Army were selected. The patients were randomly divided into the study group and the control group by random numbers method， with 49 cases in each group. The study group was treated with Qiangli Loquat Dew combined with western medicine， while the control group was treated with western medicine. Clinical efficacy， recovery time of clinical symptoms， inflammatory factors， quality of life and adverse reactions of patients were compared between the two groups. Results The total effective rate of the study group after 2 weeks of treatment was higher than that of the control group， and the difference was statistically significant (P < 0.05). The remission time of cough， sputum， fever and lung ralogue symptoms in the study group was shorter than those in the control group， and the differences were statistically significant (all P < 0.05). The serum levels of interleukin-6 (IL-6)， IL-8 and tumor necrosis factor-α (TNF-α) of patients in the two groups decreased after 2 weeks of treatment compared with those before treatment， and the study group were lower than those in the control group， the differences were statistically significant (all P < 0.05). The scores of physiological function， physical pain， role physical， general health， social function， energy， emotional function and mental status of patients in the two groups after 2 weeks of treatment were all higher than those before treatment， and the scores of the study group were higher than those in the control group， the differences were statistically significant (all P < 0.05). There was no significant difference of the incidence of adverse reactions of patients between the two groups (P > 0.05). Conclusion In the treatment of acute exacerbation of chronic bronchitis with combination of Qiangli Loquat Dew and Western medicine， the curative effect is definite， the level of inflammatory factors can be effectively improved， and the quality of life of patients can be improved without increasing the incidence of adverse reactions., 百拇医药(范洪涛 黄小平 黄鑫成)
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