[摘要] 肝细胞癌(HCC)是常见的恶性肿瘤之一，具有较高的致死率，HCC的早期有效诊断至关重要。微小RNA(miRNA)参与肝癌细胞增殖、分化、迁移、新生血管生成、细胞凋亡等活动过程，有望成为协助肝癌的诊断、治疗及预后判断的新生生物标志物。本文主要将血清或血浆的miRNA在肝癌临床应用中的研究进展作一综述，旨在为肝癌的临床诊断、治疗以及评估肝癌的预后提供新思路。

    [关键词] 微小RNA;肝细胞癌;早期检测;治疗;预后

    [中图分类号] R735.7 [文献标识码] A [文章编号] 1673-7210(2020)06(a)-0045-04

    [Abstract] Hepatocellular carcinoma (HCC) was one of the common malignant tumors with a high mortality rate. Early and effective diagnosis of HCC was essential. MicroRNA (miRNA) was involved in the proliferation ......