柴胡平胃散在防治肿瘤化疗相关癌因性疲乏中的效果(1)
[摘要] 目的 觀察柴胡平胃散在防治肿瘤化疗相关的癌因性疲乏(CRF)的临床效果。 方法 选取2017年1月—2018年12月海南省中医院肿瘤科收治的住院接受化疗的患者60例，按照随机数字表法分为柴胡平胃散组和常规组，每组30例。常规组予以最佳对症支持治疗，柴胡平胃散组在常规组对症支持治疗基础上于化疗后第1天开始口服柴胡平胃散，连续口服7 d。观察两组治疗前后疲乏程度、生活质量评分、骨髓抑制、消化道反应、营养状况及免疫功能的变化。 结果 治疗前，两组CRF评分比较，差异无统计学意义(P > 0.05)。治疗1周后，柴胡平胃散组CRF评分与治疗前比较，差异无统计学意义(P > 0.05)，常规组情感与认知评分与治疗前比较，差异无统计学意义(P > 0.05)，常规组行为、感觉评分均较治疗前升高，差异均有统计学意义(均P < 0.05)。治疗1周后，柴胡平胃散组行为、感觉评分均较常规组降低，差异均有统计学意义(均P < 0.05)，但情感与认知评分与常规组比较，差异无统计学意义(P > 0.05)。治疗前，两组Karnofsky功能状态评分(KPS评分)比较，差异无统计学意义(P > 0.05)，治疗1周后，柴胡平胃散组KPS评分与治疗前比较，差异无统计学意义(P > 0.05)，但常规组KPS评分较治疗前降低，差异有高度统计学意义(P < 0.01)。治疗1周后，柴胡平胃散组KPS评分高于常规组，差异有统计学意义(P < 0.05)。柴胡平胃散组化疗的消化道反应和骨髓抑制发生率明显低于常规组，差异有统计学意义(P < 0.05)。治疗前，两组患者的CD4+/CD8+比较，差异无统计学意义(P < 0.05)，治疗1周后，柴胡平胃散组CD4+/CD8+较治疗前升高，差异有统计学意义(P < 0.05)，但常规组CD4+/CD8+与治疗前比较，差异无统计学意义(P > 0.05)。治疗1周后，柴胡平胃散组的CD4+/CD8+明显高于常规组，差异有高度统计学意义(P < 0.01)。治疗前，两组主观整体营养状况评量表(PG-SGA)评分比较，差异无统计学意义(P > 0.05)，治疗1周后，柴胡平胃散组PG-SGA评分与治疗前比较，差异无统计学意义(P > 0.05)，但常规组PG-SGA评分较治疗前升高，差异有统计学意义(P < 0.05)。治疗1周后，柴胡平胃散组的PG-SGA评分明显低于常规组，差异有高度统计学意义(P < 0.01)。 结论 化疗同时口服柴胡平胃散可以在一定程度上减轻癌症疲乏程度、改善生活质量、减少消化道反应和骨髓抑制的发生率，且可以增强免疫功能，对防治化疗所致的CRF具有一定的效果。
[关键词] 柴胡平胃散;癌因性疲乏;化疗
[中图分类号] R273 [文献标识码] A [文章编号] 1673-7210(2020)08(b)-0086-05
[Abstract] Objective To observe the clinical effect of Chaihu Pingwei Powder on the prevention and treatment of cancer-related fatigue (CRF) caused by chemotherapy. Methods A total of 60 hospitalized patients receiving chemotherapy admitted to the Department of Oncology， Hainan Hospital of Traditional Chinese Medicine from January 2017 to December 2018 were selected. According to the random number table method， they were divided into the Chaihu Pingwei Powder group and the conventional group， with 30 patients in each group. The conventional group received the best symptomatic and supportive treatment， while the Chaihu Pingwei Powder group was given oral administration of Chaihu Pingwei Powder on the first day after chemotherapy based on the symptomatic and supportive treatment of the conventional group， and was taken orally for seven days consecutively. The changes of fatigue， quality of life score， bone marrow suppression， gastrointestinal reaction， nutritional status and immune function were observed before and after treatment in the two groups. Results Before treatment， there was no significant difference in CRF scores between the two groups (P > 0.05). After one week of treatment， CRF score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P > 0.05). The emotional and cognitive scores of the conventional group showed no statistically significant difference from those before treatment (P > 0.05)， behavioral and sensory scores of the conventional group increased compared with those before treatment， with statistically significant differences (all P < 0.05). After one week of treatment， the behavioral and sensory scores of Chaihu Pingwei Powder group were lower than those of the conventional group， with statistically significant differences (all P < 0.05)， while the emotional and cognitive scores were not significantly different from those of the conventional group (P > 0.05). Before treatment， there was no significant difference in Karnofsky functional status score (KPS score) between the two groups (P > 0.05). After one week of treatment， KPS score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P > 0.05)， while KPS score of the conventional group was lower than that before treatment， with highly statistically significant difference (P < 0.01). After one week of treatment， KPS score of Chaihu Pingwei Powder group was higher than that of the conventional group， with statistically significant difference (P < 0.05). The incidence of gastrointestinal reaction and bone marrow suppression in Chaihu Pingwei Powder group was significantly lower than that in the conventional group， and the difference was statistically significant (P < 0.05). Before treatment， there was no statistically significant difference in CD4+/CD8+ between the two groups (P < 0.05). After one week of treatment， CD4+/CD8+ of the Chaihu Pingwei Powder group was increased compared with that before treatment， and the difference was statistically significant (P < 0.05)， while CD4+/CD8+ of the conventional group was not significantly different from that before treatment (P > 0.05). After one week of treatment， CD4+/CD8+ of Chaihu Pingwei Powder group was significantly higher than that of the conventional group， and the difference was highly statistically significant (P < 0.01). Before treatment， there was no significant difference in the subjective overall nutritional status rating scale (PG-SGA) scores between the two groups (P > 0.05). After one week of treatment， PG-SGA score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P > 0.05)， while PG-SGA score of the conventional group was increased compared with that before treatment， with statistically significant difference (P > 0.05). After one week of treatment， the PG-SGA score of Chaihu Pingwei Powder group was significantly lower than that of the conventional group， and the difference was highly statistically significant (P < 0.01). Conclusion At the same time of chemotherapy， oral Chaihu Pingwei Powder can significantly reduce the degree of cancer fatigue fo some extent， improve the quality of life， reduce the incidence of gastrointestinal reaction and bone marrow suppression， and can enhance the immune function， has a certain effect on the prevention and treatment of CRF caused by chemotherapy., http://www.100md.com(姜靖雯 张慧 朱风婷)
[关键词] 柴胡平胃散;癌因性疲乏;化疗
[中图分类号] R273 [文献标识码] A [文章编号] 1673-7210(2020)08(b)-0086-05
[Abstract] Objective To observe the clinical effect of Chaihu Pingwei Powder on the prevention and treatment of cancer-related fatigue (CRF) caused by chemotherapy. Methods A total of 60 hospitalized patients receiving chemotherapy admitted to the Department of Oncology， Hainan Hospital of Traditional Chinese Medicine from January 2017 to December 2018 were selected. According to the random number table method， they were divided into the Chaihu Pingwei Powder group and the conventional group， with 30 patients in each group. The conventional group received the best symptomatic and supportive treatment， while the Chaihu Pingwei Powder group was given oral administration of Chaihu Pingwei Powder on the first day after chemotherapy based on the symptomatic and supportive treatment of the conventional group， and was taken orally for seven days consecutively. The changes of fatigue， quality of life score， bone marrow suppression， gastrointestinal reaction， nutritional status and immune function were observed before and after treatment in the two groups. Results Before treatment， there was no significant difference in CRF scores between the two groups (P > 0.05). After one week of treatment， CRF score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P > 0.05). The emotional and cognitive scores of the conventional group showed no statistically significant difference from those before treatment (P > 0.05)， behavioral and sensory scores of the conventional group increased compared with those before treatment， with statistically significant differences (all P < 0.05). After one week of treatment， the behavioral and sensory scores of Chaihu Pingwei Powder group were lower than those of the conventional group， with statistically significant differences (all P < 0.05)， while the emotional and cognitive scores were not significantly different from those of the conventional group (P > 0.05). Before treatment， there was no significant difference in Karnofsky functional status score (KPS score) between the two groups (P > 0.05). After one week of treatment， KPS score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P > 0.05)， while KPS score of the conventional group was lower than that before treatment， with highly statistically significant difference (P < 0.01). After one week of treatment， KPS score of Chaihu Pingwei Powder group was higher than that of the conventional group， with statistically significant difference (P < 0.05). The incidence of gastrointestinal reaction and bone marrow suppression in Chaihu Pingwei Powder group was significantly lower than that in the conventional group， and the difference was statistically significant (P < 0.05). Before treatment， there was no statistically significant difference in CD4+/CD8+ between the two groups (P < 0.05). After one week of treatment， CD4+/CD8+ of the Chaihu Pingwei Powder group was increased compared with that before treatment， and the difference was statistically significant (P < 0.05)， while CD4+/CD8+ of the conventional group was not significantly different from that before treatment (P > 0.05). After one week of treatment， CD4+/CD8+ of Chaihu Pingwei Powder group was significantly higher than that of the conventional group， and the difference was highly statistically significant (P < 0.01). Before treatment， there was no significant difference in the subjective overall nutritional status rating scale (PG-SGA) scores between the two groups (P > 0.05). After one week of treatment， PG-SGA score of Chaihu Pingwei Powder group was not significantly different from that before treatment (P > 0.05)， while PG-SGA score of the conventional group was increased compared with that before treatment， with statistically significant difference (P > 0.05). After one week of treatment， the PG-SGA score of Chaihu Pingwei Powder group was significantly lower than that of the conventional group， and the difference was highly statistically significant (P < 0.01). Conclusion At the same time of chemotherapy， oral Chaihu Pingwei Powder can significantly reduce the degree of cancer fatigue fo some extent， improve the quality of life， reduce the incidence of gastrointestinal reaction and bone marrow suppression， and can enhance the immune function， has a certain effect on the prevention and treatment of CRF caused by chemotherapy., http://www.100md.com(姜靖雯 张慧 朱风婷)