[摘要]细胞自噬是真核细胞的溶酶体依赖的代谢机制之一，参与宿主抵御病原菌感染的过程。牙龈卟啉单胞菌(P.gingivalis)能够侵入血管内皮细胞并利用自噬逃避宿主清除、持续并传播感染。本文就P.gingivalis与细胞自噬相关性研究的进展作一综述。

    [关键词]牙龈卟啉单胞菌；细胞自噬；感染；血管内皮细胞

    [中图分类号]R 515[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.01.023

    Research progress on the association between Porphyromonas gingivalis and cell autophagyLiu Bin, Liang Jingping.(Dept. of Conservative Dentistry and Endodontics, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China)

    [Abstract]Autophagy is a lysosome dependent metabolic mechanism of eukaryotic cells, which is involved in the host defense progress against pathogen infection. Porphyromonas gingivalis(P. gingivalis)could invade the vascular endothelial cells and take advantage of autophagy to escape the clearance of the host, leading to the persistence and transmission of infection. The purpose of the article is to discuss the progress on the association between P. gingivalis and cell autophagy.

    [Key words]Porphyromonas gingivalis；autophagy；infection；vascular endothelial cell ......