[摘要]生长因子在牙周组织再生过程中起重要的作用，是组织修复的基本调节者，但其在体内半衰期短，直接应用达不到预期的效果。为此，国内外众多学者正致力于寻找一种能够使生长因子持续高效发挥作用的方法，其中，制备生长因子缓释微球，利用智能控释载体材料，使生长因子缓慢而持续地释放；采用基因工程技术，通过载体将生长因子的目的基因整合入目的细胞，也能使生长因子在细胞和组织中持续局限性地表达。这两种方法均有望解决生长因子不能有效发挥其生物学作用这一难题。本文就建立生长因子缓释和控释系统以及基因工程技术等研究进展作一综述。

    [关键词]生长因子；牙周组织再生；缓控释系统；基因治疗

    [中图分类号]Q 51[文献标志码]A[doi]10.3969/j.issn.1673-5749.2011.06.000

    Effective releasing way of growth factors in periodontal tissue regenerationWang Cha, Xu Yan.(Dept. of Periodontics and Mucosa Disease, The Affiliated Hospital of Stomatology, Anhui Medical University, Hefei 230032, China)

    [Abstract]Growth factors, which are fundamental regulators of tissue repair, play an enssential role in periodon-tal tissue regeneration. But we can’t receive desired results when applicate them directly for their elimination half-life are short in vivo. For this reason, many domestic and international scholars are exploring the ways to make growth factors releasing sustainable and effective. Preparing growth factor controlled-release microspheres or using intelligent controlled-release carrier materials can make growth factors released slowly and sustainable; Using genetic engineering, that is integrate target gene of growth factors into target cells by carriers, also can make growth factors expressing sustainable and limited in cells and tissues. Both methods are expected to solve the problem that growth factors can’t play their biological role effectively. This paper will make a review on setting up sustained and controlled release system and gene therapy. ......