[摘要]正畸牙移动是在机械应力作用下多种因子介导的牙周组织改建。随着现代试验技术的发展，研究者们开始在分子和基因水平研究正畸牙移动的生物学特征。在各种参与牙周组织改建的细胞因子中，生长因子是重要的调节因子之一。了解其在正畸牙移动过程中对牙周组织改建的具体作用机制，有助于正畸医师更好地理解正畸牙移动的生物学行为，指导其在正畸临床上的应用。本文就正畸牙移动的生物学基础、正畸牙移动过程中牙周组织的变化、生长因子在牙周组织改建中的作用等研究进展作一综述。

    [关键词]生长因子；正畸牙移动；牙周组织改建

    [中图分类号]R 783.5[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.01.000

    Effects of growth factors on the periodontal tissue remodeling during orthodontic tooth movementPeng Peng, Cai Ping. [The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)& Key Labo-ratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China]

    [Abstract]Orthodontic tooth movement is achieved by the periodontal tissue remodeling in response to mechani-cal loading and is believed to be mediated by several host mediators. With the development of modern experimen-tal techniques, the researchers have been able to investigate the biological characteristics of orthodontic tooth movement at the molecular and genetic level. The growth factor is one of the most important cytokines which play an important role in the periodontal tissue remodeling. Therefore, A thoroughly awareness of the extensional regu-latory mechanism of growth factors is essential to understand the biological behaviour of orthodontic tooth move-ment, and to the application of growth factors in orthodontic clinic. This article reviews the research progress of the biological foundation and the periodontal tissue responses during orthodontic tooth movement and effects of growth factors on the periodontal tissue remodeling. ......