[摘要]牙菌斑生物膜中的细菌是龋病发生的先决条件，而口腔内存在多种细菌生长的抑制因子，它们对细菌的生长或菌斑的形成起一定抑制作用。细菌生长的抑制因子主要来自宿主和细菌本身产生的细菌素以及其他代谢产物，本文就致龋菌生长抑制因子的种类及作用的研究进展作一综述。

    [关键词]龋病；牙菌斑；抑制因子；细菌素

    [中图分类号]R 781[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.02.016

    Growth inhibition factors for the bacteria consist of dental plaque biofilmWu Guitang, Zhou Lili, Liu Xingrong.(Dept. of Oral Medicine, The Affiliated Hospital of Stomatology of Luzhou Medical School, Luzhou 646000, China)

    [Abstract]The existence of bacteria in dental plaque is the precondition for dental caries to occur. Many inhibition factors(IF)lie in oral cavity restrain bacteria to grow and form dental plaque. These inhibition factors usually come from host and bacteriocin which generated by kinds of cariogenic bacteria, and also from kinds of metabo-lized product. This review mainly introduced research progress on the species and function of IF in growth of caries-related bacteria.

    [Key words]dental caries；dental plaque；inhibition factors；bacteriocin

    牙菌斑生物膜中有200~400种细菌，但其中仅1%~10%可以培养，以厌氧菌居多，主要致龋菌为变异链球菌(Streptococcus mutans，S.mutans)，其次是乳杆菌和黏性放线菌 ......