[摘要]梅克尔软骨来源于第一鳃弓，在下颌骨的生长发育、锤骨和砧骨的形成中起重要作用。作为下颌骨早期发育的支架，梅克尔软骨在出生之后逐渐消亡。本文就梅克尔软骨消亡的分子机制作一综述。

    [关键词]梅克尔软骨；消亡；分子机制

    [中图分类号]R 782[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.03.016

    Research progress on the molecular mechanisms for the degeneration of Meckel’s cartilageLiu Yong, Yang Rongtao, Li Zubing. [The State Key Laboratory Breeding Base of Basic Science of Stomatology(HubeiMOST)& Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China]

    [Abstract]Meckel’s cartilage which is derived from the first branchial arch plays an important role during the development and growth of the mandible and also the morphology of malleus and incus. As a supporting bar for the mandibular early development, the intermediate region of Meckel’s cartilage gradually degenerated after birth. This paper aimed to review the molecular mechanisms of the degeneration of Meckel’s cartilage.

    [Key words]Meckel’s cartilage；degeneration；molecular mechanisms

    梅克尔软骨起源于神经嵴细胞，由第一鳃弓的外胚间充质分化而来。它先以一对杆状透明软骨的形式出现，为下颌骨骨化前的下颌突生长起到支持和引导作用 ......