[摘要]富血小板纤维蛋白(PRF)是一种富含细胞因子和生长因子的自体来源的新型生物材料，被誉为新一代血小板浓缩物。其分子结构类似天然血凝块，为组织细胞提供迁移、增殖和分化的场所。近来，许多学者将PRF作为移植材料应用于口腔种植前上颌窦底提升术后的骨移植中，并获得了良好的效果。本文就PRF及其在口腔种植上颌窦底提升术中的应用进展作一综述。

    [关键词]富血小板纤维蛋白；口腔种植；上颌窦底提升

    [中图分类号]Q 813[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.03.025

    Research progress on platelet-rich fibrinYang Shimao1, Wang Mingguo2.(1. Dept. of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan 250012, China; 2. Dept. of Stomatology, Jinan Central Hospital, Jinan 250013, China)

    [Abstract]Platelet-rich fibrin(PRF)is a source of autogenic neotype biomaterial, which is rich in cytokine and growth factors, and is called new generation of platelet concentrates. The molecular constitution of PRF is similar to nature blood clot, and to provide location with migration, proliferation, and differentiation for rhagiocrine cell. Recently, many researchers use PRF as graft on the sinus floor elevation in dental implantation and win well re-sults. This article reviewed PRF and its application on sinus floor elevation in dental implantation.

    [Key words]platelet-rich fibrin；dental implantation；sinus floor elevation ......