spx蛋白调控作用的研究进展
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2012年12月1日
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[摘要]变异链球菌是人类龋病的主要致龋菌，在口腔内感受各种应激条件的变化，其致病性与其在各种应激环境中的耐受情况密切相关。spx蛋白是一种革兰阳性细菌全局性调节因子，在变异链球菌的应激耐受、生存和致龋过程中起着重要的作用。本文就spx蛋白及spx/α-C末端结构域复合体结构、非致龋菌的spx蛋白及其调控功能、变异链球菌spx蛋白及其调控作用等研究进展作一综述。
[关键词]变异链球菌；spx蛋白；应激耐受；毒力
[中图分类号]Q 51[文献标志码]A[doi]10.3969/j.issn.1673-5749.2012.06.022
Research progress on the regulation of spx proteinZhao Wei, Yu Danni.(Dept. of Stomatology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China)
[Abstract]Streptococus mutans is known as a primary pathogen of dental caries, which experiences all kinds of pressure changes in oral cavity, and its pathogenicity closely relates to the tolerance in a variety of environments. The spx protein is a global regulator in Gram-positive bacteria, and plays a particular role in stress tolerance, sur-vival and virulence of Streptococus mutans. This article reviewed the spx protein, the structure of spx/α-C terminal domain complex and the regulation of spx protein in Streptococus mutans and non-cariogenic bacterias ......
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