六郁汤对奥氮平致精神分裂症患者代谢综合征的改善作用(1)
摘要 目的：探讨六郁汤对奥氮平致精神分裂症患者代谢综合征的改善作用。方法：选取2015年1月至2017年1月恩施州精神卫生中心收治的精神分裂症合并代谢综合征患者120例，随机分为观察组与对照组，每组60例，观察组采用奥氮平联合六郁汤治疗，对照组给予奥氮平治疗，2组均治疗12周。比较2组患者临床疗效；比较治疗前后2组患者糖脂代谢指标、体重指数、血压变化；比较2组患者精神症状改善情况；统计2组患者治疗期间不良反应发生情况。结果：治疗后观察组的总有效率(93.33%)，显著高于对照组(71.67%)(P<0.01)；与治疗前比较，观察组血清FPG、HbAlc、TG水平及BMI均降低，且低于对照组(P<0.05或P<0.01)；观察组血清HDL水平升高，且高于对照组(P<0.01)，治疗后观察组DBP、SBP均较治疗前降低，且低于对照组(P<0.05或P<0.01)，治疗后2组患者PANSS评分及观察组TESS评分均较治疗前下降，且观察组低于对照组(P<0.05或P<0.01)。结论：六郁汤可有效改善奥氮平致精神分裂症代谢综合征患者糖脂代谢，有效调节患者血压，并改善其精神症状，安全性良好。
关键词 六郁汤；奥氮平；精神分裂症；代谢综合征
Abstract Objective：To explore the improvement effects of Liuyu Decoction on olanzapine-induced metabolism syndrome of schizophrenic patients. Methods：A total of 120 cases schizophrenic with metabolic syndrome patients were selected and randomly divided into observation group (n=60) and control group (n=60). The observation group was treated with Liuyu Decoction and olanzapine， and the control group was treated with olanzapine. Both groups were treated for 12 weeks. The clinical efficacy of 2 groups was compared， and the changes of the glucose and lipid metabolism， body mass index， blood press of 2 groups before and after treatment were compared； The improvement of psychiatric symptoms of 2 groups was compared； The adverse reactions of 2 groups during the treatment were recorded. Results：The total effective rate of observation group (93.33%) was higher than control group (71.67%) (P<0.01)； Compared with before treatment， the levels of serum FPG， HbAlc， TG and BMI of observation group decreased after treatment， and which were lower than control group (P<0.05 or P<0.01)； The serum HDL of observation group after treatment increased than that before treatment， and which was higher than control group (P<0.01). The DBP and SBP of observation group after treatment decreased than that before treatment， and which were lower than control group (P<0.05 or P<0.01). The scores of PANSS and TESS of 2 groups after treatment decreased than that before treatment， and observation group was lower than control group (P<0.05 or P<0.01). Conclusion：Liuyu Decoction can effectively improve the glucose and lipid metabolism of olanzapine-induced metabolism syndrome of schizophrenic patients， effectively regulate the blood press of patients and improve the psychiatric symptoms with good safety.
Key Words Liuyu Decoction； Olanzapine； Schizophrenic； Metabolism syndrome
中图分类号：R277.7文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.12.033
近年来，随着对第二代抗精神病药物治疗精神分裂症的研究愈发深入，其不良反应也逐渐引发关注，如奥氮平治疗精神分裂症引发的代谢综合征，其临床主要表现为肥胖、糖脂代谢紊乱、高血壓等，不仅严重影响精神分裂症患者的治疗效果，导致其临床应用受限，甚至会威胁患者生命安全[1-2]。中医认为代谢综合征是由于脾肾等腑脏功能失调，从而使得气血津液运行不畅、排泄障碍，形成高血糖、高血压等虚实夹杂之证，因此调理腑脏功能，化解湿浊是其治疗的关键[3]。本研究旨在探讨六郁汤对精神分裂症合并代谢综合征的改善作用，现报道如下。, http://www.100md.com(杨玲)
关键词 六郁汤；奥氮平；精神分裂症；代谢综合征
Abstract Objective：To explore the improvement effects of Liuyu Decoction on olanzapine-induced metabolism syndrome of schizophrenic patients. Methods：A total of 120 cases schizophrenic with metabolic syndrome patients were selected and randomly divided into observation group (n=60) and control group (n=60). The observation group was treated with Liuyu Decoction and olanzapine， and the control group was treated with olanzapine. Both groups were treated for 12 weeks. The clinical efficacy of 2 groups was compared， and the changes of the glucose and lipid metabolism， body mass index， blood press of 2 groups before and after treatment were compared； The improvement of psychiatric symptoms of 2 groups was compared； The adverse reactions of 2 groups during the treatment were recorded. Results：The total effective rate of observation group (93.33%) was higher than control group (71.67%) (P<0.01)； Compared with before treatment， the levels of serum FPG， HbAlc， TG and BMI of observation group decreased after treatment， and which were lower than control group (P<0.05 or P<0.01)； The serum HDL of observation group after treatment increased than that before treatment， and which was higher than control group (P<0.01). The DBP and SBP of observation group after treatment decreased than that before treatment， and which were lower than control group (P<0.05 or P<0.01). The scores of PANSS and TESS of 2 groups after treatment decreased than that before treatment， and observation group was lower than control group (P<0.05 or P<0.01). Conclusion：Liuyu Decoction can effectively improve the glucose and lipid metabolism of olanzapine-induced metabolism syndrome of schizophrenic patients， effectively regulate the blood press of patients and improve the psychiatric symptoms with good safety.
Key Words Liuyu Decoction； Olanzapine； Schizophrenic； Metabolism syndrome
中图分类号：R277.7文献标识码：Adoi：10.3969/j.issn.1673-7202.2017.12.033
近年来，随着对第二代抗精神病药物治疗精神分裂症的研究愈发深入，其不良反应也逐渐引发关注，如奥氮平治疗精神分裂症引发的代谢综合征，其临床主要表现为肥胖、糖脂代谢紊乱、高血壓等，不仅严重影响精神分裂症患者的治疗效果，导致其临床应用受限，甚至会威胁患者生命安全[1-2]。中医认为代谢综合征是由于脾肾等腑脏功能失调，从而使得气血津液运行不畅、排泄障碍，形成高血糖、高血压等虚实夹杂之证，因此调理腑脏功能，化解湿浊是其治疗的关键[3]。本研究旨在探讨六郁汤对精神分裂症合并代谢综合征的改善作用，现报道如下。, http://www.100md.com(杨玲)
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