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编号:13604101
益气活血方联合四联疗法治疗幽门螺杆菌阳性的慢性萎缩性胃炎的疗效及对胃蛋白酶原的影响(1)
http://www.100md.com 2018年1月15日 《世界中医药》 20182
     摘要 目的:探讨益气活血方联合四联疗法治疗中医辨证为脾胃气虚血瘀型的幽门螺杆菌(Hp)阳性胃体为主型慢性萎缩性胃炎(CAG)的疗效及对胃蛋白酶原(PG)、炎性反应因子的影响。方法:选取2013年5月至2016年10月唐山工人医院收治的Hp阳性CAG患者87例,随机分为观察组(n=45)和对照组(n=42)。对照组采用四联疗法治疗,观察组采用益气活血方联合四联疗法治疗,2组分别于治疗前(第0天)及治疗后(第40天)进行PG检测。统计2组临床疗效,比较2组PG和炎性反应因子水平的变化。结果:治疗后,观察组治疗有效率84.44%,显著高于对照组的64.29%(P<0.05);治疗后2组PGⅠ含量和PGⅠ/PGⅡ均显著高于治疗前(P<0.05或P<0.01),且观察组显著高于对照组(P<0.05或P<0.01);治疗后2组PGⅡ含量均较治疗前无明显变化(P>0.05),且2组间差异无统计学意义(P>0.05);治疗后2组IL-6、TNF-α、CRP均显著低于治疗前(P<0.01),且觀察组低于对照组(P<0.01)。结论:益气活血方联合四联疗法能改善Hp阳性CAG患者的主要临床症状,增强胃黏膜的分泌功能,提高血清中PG的含量,降低炎性反应因子水平,安全有效,值得临床推广应用。
, 百拇医药
    关键词 幽门螺杆菌阳性;慢性萎缩性胃炎;益气活血方;四联疗法;胃蛋白酶原

    Abstract Objective:To discuss the effects of Yiqi Huoxue Fang combined with quadruple therapy on chronic atrophic gastritis (CAG) of helicobacter pylori (HP) positive stomach body in the type of spleen and stomach qi deficiency and blood stasis type diagnosed by Chinese medicine discrimination and its effects on pepsinogen (PG) and inflammatory factors.Methods:A total of 87 cases of Hp positive CAG admitted and treated in Tangshan Workers′ Hospital from May 2013 to October 2016 were randomly divided into experimental group (n=45) and control group (n=42).The control group was treated with quadruple therapy,and the experimental group treated by Yiqi Huoxue Fang combined with quadruple therapy.PG test was performed before treatment (day 0) and after treatment (day 40) in the two groups.The clinical curative effect of the two groups and the changes of PG and inflammatory factors were compared.Results:After treatment,the effective rate of the experimental group was 84.44%,which was significantly higher than 64.29% of the control group (P<0.05).After treatment,PGⅠ content and PGⅠ/PGⅡ were significantly higher than those before treatment (P<0.05 or P<0.01),and the experimental group was significantly higher than the control group (P<0.05 or P<0.01); the contents of PGⅡ in two groups had not significantly changed compared with those before treatment (P>0.05),and there was no difference between the two groups (P>0.05); after treatment,IL-6,TNF-α and CRP of the two groups were significantly lower than those before treatment (P<0.01),and the experiment group was lower than the control group (P<0.01).Conclusion:Yiqi Huoxue Fang combined with quadruple therapy can improve the main clinical symptoms of Hp positive CAG patients,enhance the secretion of gastric mucosa,improve the content of PG in serum and reduce the level of inflammatory factors,which was safe and effective and worthy of clinical application., 百拇医药(王永增 马艳荣 刘玉生 司雁菱 张建博 孙岭)
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