中西医结合治疗围绝经期综合征的疗效(1)
摘要 目的：探討坤泰胶囊+知柏地黄丸+维生素E胶囊在治疗围绝经期综合征的应用效果。方法：选取2015年1月至2016年5月医院门诊就诊的125例围绝经期患者，将其随机分成2组，观察者75例，给予坤泰胶囊+知柏地黄丸+维生素E胶囊治疗。对照组50例，给予激素替代治疗(HRT)。通过检测治疗3个月、6个月2组血清FSH、E2水平、子宫内膜厚度、肝肾功能指标(ALT，AST，BUN)、KI评分和不良反应情况来观察2组临床疗效，结果：治疗3个月、6个月，观察组血清FSH、E2水平明显低于对照组(P<0.05);2组子宫内膜厚度无明显变化(P>0.05);肝肾功能指标无明显变化(P>0.05);治疗3个月，2组KI评分比较，差异无统计学意义(P>0.05)。治疗6个月，观察组KI评分较对照组明显降低(P<0.05);治疗3个月、6个月观察组不良反应发生率明显低于对照组(P<0.05)。结论：坤泰胶囊+知柏地黄丸+维生素E胶囊联合应用可明显改善围绝经期症状，调节性激素水平，且无明显的不良反应，安全性高。
关键词 坤泰胶囊;知柏地黄丸;维生素E;围绝经期综合征;克龄蒙;激素替代治疗
, http://www.100md.com
Observation on Clinical Efficacy of Integrated Traditional Chinese and Western Medicine
in Treating the Perimenopause Syndrome
Ding Renbo， Lyu Huijuan， Wang Tiantian
(Department of Obstetrics and Gynecology of Zhengzhou Maternity and Child Care Hospital， Zhengzhou 450000， China)
Abstract Objective：To explore the effects of Kuntai Capsule+Zhibai Dihuang Pills+Vitamin E Capsule in the treatment of perimenopause syndrome. Methods：A total of 125 cases of patients with perimenopause syndrome who were treated in our hospital from January 2015 to May 2016 were randomly divided into two groups. The 75 patients in the observation group were treated by Kuntai capsule+Zhibai Dihuang pills+vitamin E capsule， and the 50 patients in the control group were treated by hormone replacement therapy (HRT). Clinical efficacy was observed by testing E2 and FSH levels of the serum， endometrial thickness， Liver and kidney function index (ALT、AST、BUN)， KI score after treatment for 3 months and 6 months. Results：E2 and FSH levels of the serum in the observation group after treatment for 3 months and 6 months were significantly lower than the control group; Endometrial thickness were not significantly changed between the two groups after treatment for 3 months and 6 months; Liver and kidney function index (the levels of ALT、AST、BUN in the serum) were not significantly changed between the two groups after treatment for 3 months and 6 months; KI score after treatment for 3 months and 6 months was not significantly changed between the two groups; The incidence of adverse reactions in the observation group was significantly lower than the control group after treatment for 3 months and 6 months. Conclusion：Kuntai Capsule+Zhibai Dihuang Pills+Vitamin E Capsule can effectively improve perimenopause syndrome， regulate sex hormone levels， without significant adverse reactions and with high safety.
Key Words Kuntai capsule; Zhibai Dihuang Pills; Vitamin E; Perimenopause syndrome; Climen; Hormone replacement therapy (HRT), 百拇医药(丁仁波 吕会娟 王甜甜)
关键词 坤泰胶囊;知柏地黄丸;维生素E;围绝经期综合征;克龄蒙;激素替代治疗
, http://www.100md.com
Observation on Clinical Efficacy of Integrated Traditional Chinese and Western Medicine
in Treating the Perimenopause Syndrome
Ding Renbo， Lyu Huijuan， Wang Tiantian
(Department of Obstetrics and Gynecology of Zhengzhou Maternity and Child Care Hospital， Zhengzhou 450000， China)
Abstract Objective：To explore the effects of Kuntai Capsule+Zhibai Dihuang Pills+Vitamin E Capsule in the treatment of perimenopause syndrome. Methods：A total of 125 cases of patients with perimenopause syndrome who were treated in our hospital from January 2015 to May 2016 were randomly divided into two groups. The 75 patients in the observation group were treated by Kuntai capsule+Zhibai Dihuang pills+vitamin E capsule， and the 50 patients in the control group were treated by hormone replacement therapy (HRT). Clinical efficacy was observed by testing E2 and FSH levels of the serum， endometrial thickness， Liver and kidney function index (ALT、AST、BUN)， KI score after treatment for 3 months and 6 months. Results：E2 and FSH levels of the serum in the observation group after treatment for 3 months and 6 months were significantly lower than the control group; Endometrial thickness were not significantly changed between the two groups after treatment for 3 months and 6 months; Liver and kidney function index (the levels of ALT、AST、BUN in the serum) were not significantly changed between the two groups after treatment for 3 months and 6 months; KI score after treatment for 3 months and 6 months was not significantly changed between the two groups; The incidence of adverse reactions in the observation group was significantly lower than the control group after treatment for 3 months and 6 months. Conclusion：Kuntai Capsule+Zhibai Dihuang Pills+Vitamin E Capsule can effectively improve perimenopause syndrome， regulate sex hormone levels， without significant adverse reactions and with high safety.
Key Words Kuntai capsule; Zhibai Dihuang Pills; Vitamin E; Perimenopause syndrome; Climen; Hormone replacement therapy (HRT), 百拇医药(丁仁波 吕会娟 王甜甜)