左金丸治疗对肝火犯胃证反流性食管炎患者胃肠道自主神经功能的影响(1)
摘要 目的：察和分析左金丸治療对肝火犯胃证反流性食管炎患者胃肠道自主神经功能的影响。方法：选取2016年1月至2017年1月中医科学院广安门医院南区消化科收治的肝火犯胃证反流性食管炎患者78例，将患者随机分为观察组及对照组，每组39例。对照组予以西药奥美拉唑肠溶胶囊结合枸橼酸莫沙必利片口服治疗，观察组则加以左金丸口服治疗，分别在治疗前、治疗后记录2组患者的临床症状积分、内镜分级，自主神经检测数值，并进行临床疗效评定。结果：经过1个月治疗后，对照组的治疗总有效率为84.61%，观察组的总有效率为94.44%，观察组的总有效率优于对照组(P<0.05)；内镜下可见观察组的改善程度明显优于对照组(P<0.05)；2组的临床症状积分和反流病诊断问卷(RDQ)评分均较治疗前降低(P<0.05)，且观察组优于对照组(P<0.05)；2组治疗后的LF提高，HF降低(P<0.05)，观察组优于对照组(P<0.05)。结论：结合左金丸治疗肝火犯胃证反流性食管炎可以更加有效的调节患者的胃肠道自主神经功能，缓解反酸、胸骨后灼痛等临床症状，提高临床疗效。
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关键词 左金丸；反流性食管炎；肝火犯胃；反流病诊断问卷评分；内镜分级；自主神经功能；临床疗效；机制
Abstract Objective：To observe and analyze the effects of Zuojin Pill on gastrointestinal autonomic nerve function in treating reflux esophagitis with liver fire invading stomach syndrome.Methods：A total of 78 cases of reflux esophagitis patients with liver fire invading stomach syndrome who were admitted in our hospital from January 2016 to January 2017 were randomly divided into observation group and control group，with 39 cases in each group.The control group was given western medicine Omeprazole Enteric-coated Capsules with Mosapride Citrate Tablets for oral treatment，and observation group was given oral administration of Zuojin Pill.The clinical symptoms，endoscopic grading，autonomic detection value，and the clinical curative effect evaluation before and after treatment were recorded respectively.Results：After 1 month of treatment，1) the total effective rate of treatment group was 84.61%，and the total effective rate of observation group was 94.44%，which was better than 84.61% in the treatment group (P<0.05)； 2) under endoscopy，the degree of improvement in the observation group was significantly better than the control group (P<0.05)； 3) the clinical symptoms scores and RDQ of two groups were lower than those before treatment (P<0.05)，and the observation group was better than the control group (P<0.05)； 4) after treatment，LF of both groups were increased，and HF decreased (P<0.05).The observation group was better than the control group (P<0.05).Conclusion：Zuojin Pill in treating reflux esophagitis with liver fire invading stomach syndrome can more effectively regulate the patient′s gastrointestinal autonomic nerve function，relieve the clinical symptoms of acid reflux，pain behind the sternum，and improve clinical curative effect，which is worthy of promotion and application.
Key Words Zuojin Pill； Reflux esophagitis； liver fire invading stomach； RDQ； Endoscopic grading； Autonomic nervous function； Clinical curative effect； Mechanism, 百拇医药(张博 李乔 谢冰昕)
, http://www.100md.com
关键词 左金丸；反流性食管炎；肝火犯胃；反流病诊断问卷评分；内镜分级；自主神经功能；临床疗效；机制
Abstract Objective：To observe and analyze the effects of Zuojin Pill on gastrointestinal autonomic nerve function in treating reflux esophagitis with liver fire invading stomach syndrome.Methods：A total of 78 cases of reflux esophagitis patients with liver fire invading stomach syndrome who were admitted in our hospital from January 2016 to January 2017 were randomly divided into observation group and control group，with 39 cases in each group.The control group was given western medicine Omeprazole Enteric-coated Capsules with Mosapride Citrate Tablets for oral treatment，and observation group was given oral administration of Zuojin Pill.The clinical symptoms，endoscopic grading，autonomic detection value，and the clinical curative effect evaluation before and after treatment were recorded respectively.Results：After 1 month of treatment，1) the total effective rate of treatment group was 84.61%，and the total effective rate of observation group was 94.44%，which was better than 84.61% in the treatment group (P<0.05)； 2) under endoscopy，the degree of improvement in the observation group was significantly better than the control group (P<0.05)； 3) the clinical symptoms scores and RDQ of two groups were lower than those before treatment (P<0.05)，and the observation group was better than the control group (P<0.05)； 4) after treatment，LF of both groups were increased，and HF decreased (P<0.05).The observation group was better than the control group (P<0.05).Conclusion：Zuojin Pill in treating reflux esophagitis with liver fire invading stomach syndrome can more effectively regulate the patient′s gastrointestinal autonomic nerve function，relieve the clinical symptoms of acid reflux，pain behind the sternum，and improve clinical curative effect，which is worthy of promotion and application.
Key Words Zuojin Pill； Reflux esophagitis； liver fire invading stomach； RDQ； Endoscopic grading； Autonomic nervous function； Clinical curative effect； Mechanism, 百拇医药(张博 李乔 谢冰昕)
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