“脑心同治”科技文献计量分析研究(1)
摘要 目的：通过文献，全面分析“脑心同治”理论发展状况。方法：以中国知网(CNKI)、PubMed数据库为文献来源，检索2001至2018年“脑心同治”研究的文献，利用Bicomb2工具对文献年代、期刊、作者、科研机构进行统计学分析；利用可视化工具Ucinet6和NetDraw2.084研究文献关键词共现网络特征。结果：“脑心同治”文献数量和质量稳步提升，研究热点为基于脑心同治理论开发的中药大品种“丹红注射液”和“脑心通胶囊”在治疗心脑血管疾病的应用，主要内容为临床有效性和安全性、分子机理、物质基础等方面，并已取得了显著成果。结论：“脑心同治”理论的临床应用越来越广泛，“脑心同治”理论更加系统和完善。
关键词 脑心同治；科技文献；计量分析；脑心通胶囊；丹红注射液；脑梗死；冠心病；共现网络
Abstract Objective：To comprehensively understand the development of “Treating both Brain and Heart” theory through literature.Methods：The China Knowledge Network (CNKI)，PubMed database were applied as literture sources to search the literature from 2001-2018 about “Treating both Brain and Heart”.The Bicomb2 tool was used to conduct statistical analysis on the age of document，the periodicals，the author and scientific research institutions.The visual tools such as Ucinet6 and NetDraw2.084 were used to study the co-existing network characteristics of the keywords in literature.Results：The quality and quantity of “Treating both Brain and Heart” literature has been rising steadily.The research hotspot is the clinical efficacy and safety of the large-scale Chinese herbal medicines “Danhong Injection” and “Naoxintong Capsule” developed based on the theory of treating both brain and heart.In treating cardiovascular and cerebrovascular diseases，the significant results have been achieved in these aspects including sexuality，molecular mechanism and material basis.Conclusion：The theory of “Treating both Brain and Heart” is more and more widely used in clinical practice，and the theory of “Treating both Brain and Heart” is more systematic and perfect.
Key Words Treating both Brain and Heart； Scientific literature； Metrology analysis； Naoxintong Capsule； Danhong Injection； Cerebral infarction； Coronary heart disease； Co-occurrence network
中圖分类号：R25 文献标识码：A doi：10.3969/j.issn.1673-7202.2018.12.062
“脑心同治”是赵步长教授2001年提出的中医药治疗的新观点[1]，在第五次全国中西医结合血瘀证及活血化瘀研究学术大会上首次提出后，引起了强烈的反响。“脑心同治”的观点从提出距今不到20年的时间，其相关的研究已经在不同层面广泛展开，已从临床观点发展成为中医学术理论和心脑血管病诊疗的广泛共识，并成立了中国中西医结合学会脑心同治专业委员会、脑心同治研究中心和脑心同治研究院等学术研究组织和机构。为系统全面的归纳总结“脑心同治”研究取得的成果和研究方向，本文采用科技文献计量分析方法，对2001—2018年“脑心同治”研究的科技文献进行计量学分析，通过“脑心同治”及其代表性药物“丹红注射液”和“脑心通胶囊”科技文献的数量与分布情况，揭示其研究现状和发展方向，梳理“脑心同治”研究的脉络，为“脑心同治”理论学术研究的深入开展提供参考。现报道如下。
1 资料与方法
1.1 文献来源 以中国知网(CNKI)、PubMed数据库为文献来源，检索2001年1月1日至2018月3月31日“脑心同治”理论研究、基础研究、临床应用等相关文献资料。
1.2 检索策略 1)CNKI数据库检索方式，主题=“脑心同治”或含“丹红注射液”或含“脑心通胶囊”(模糊检索)。2)PubMed数据库检索方式，PubMed=“naoxintong capsule”or“danhong injection”。, http://www.100md.com(逯莉 刘峰 彭修娟)
关键词 脑心同治；科技文献；计量分析；脑心通胶囊；丹红注射液；脑梗死；冠心病；共现网络
Abstract Objective：To comprehensively understand the development of “Treating both Brain and Heart” theory through literature.Methods：The China Knowledge Network (CNKI)，PubMed database were applied as literture sources to search the literature from 2001-2018 about “Treating both Brain and Heart”.The Bicomb2 tool was used to conduct statistical analysis on the age of document，the periodicals，the author and scientific research institutions.The visual tools such as Ucinet6 and NetDraw2.084 were used to study the co-existing network characteristics of the keywords in literature.Results：The quality and quantity of “Treating both Brain and Heart” literature has been rising steadily.The research hotspot is the clinical efficacy and safety of the large-scale Chinese herbal medicines “Danhong Injection” and “Naoxintong Capsule” developed based on the theory of treating both brain and heart.In treating cardiovascular and cerebrovascular diseases，the significant results have been achieved in these aspects including sexuality，molecular mechanism and material basis.Conclusion：The theory of “Treating both Brain and Heart” is more and more widely used in clinical practice，and the theory of “Treating both Brain and Heart” is more systematic and perfect.
Key Words Treating both Brain and Heart； Scientific literature； Metrology analysis； Naoxintong Capsule； Danhong Injection； Cerebral infarction； Coronary heart disease； Co-occurrence network
中圖分类号：R25 文献标识码：A doi：10.3969/j.issn.1673-7202.2018.12.062
“脑心同治”是赵步长教授2001年提出的中医药治疗的新观点[1]，在第五次全国中西医结合血瘀证及活血化瘀研究学术大会上首次提出后，引起了强烈的反响。“脑心同治”的观点从提出距今不到20年的时间，其相关的研究已经在不同层面广泛展开，已从临床观点发展成为中医学术理论和心脑血管病诊疗的广泛共识，并成立了中国中西医结合学会脑心同治专业委员会、脑心同治研究中心和脑心同治研究院等学术研究组织和机构。为系统全面的归纳总结“脑心同治”研究取得的成果和研究方向，本文采用科技文献计量分析方法，对2001—2018年“脑心同治”研究的科技文献进行计量学分析，通过“脑心同治”及其代表性药物“丹红注射液”和“脑心通胶囊”科技文献的数量与分布情况，揭示其研究现状和发展方向，梳理“脑心同治”研究的脉络，为“脑心同治”理论学术研究的深入开展提供参考。现报道如下。
1 资料与方法
1.1 文献来源 以中国知网(CNKI)、PubMed数据库为文献来源，检索2001年1月1日至2018月3月31日“脑心同治”理论研究、基础研究、临床应用等相关文献资料。
1.2 检索策略 1)CNKI数据库检索方式，主题=“脑心同治”或含“丹红注射液”或含“脑心通胶囊”(模糊检索)。2)PubMed数据库检索方式，PubMed=“naoxintong capsule”or“danhong injection”。, http://www.100md.com(逯莉 刘峰 彭修娟)