叶静 马长宏 赵龙山

    摘要 目的：考察不同品种、不同批次的常见市售中药材中汞(Hg)含量，为中药材中汞的限量控制及市场监管提供有力依据。方法：采用微波消解法消解样品，以铋(Bi)元素为内标，用电感耦合等离子体质谱法测定不同批次的11种中药材(人参、白芍、甘草、枸杞子、海藻、黄芪、金银花、山楂、水蛭、西洋参、昆布)中Hg元素的含量，并采用SPSS软件进行聚类分析。结果：汞元素线性关系良好，相关系数r≥0.999 0，汞元素的检出限为0.006 μg/L，平均回收率为100.9%，RSD为1.9%，重复性和精密度的RSD分别为1.06%和2.48%，均≤5%;有12批中药材汞含量超标，Hg含量受中药材自身特性及产地影响较大，系统聚类分析结果表明有11批次的中药材Hg含量差异较大。结论：该方法适用于大批量市售中药材中汞元素的含量考察及结果分析。

    关键词 中药材;汞;含量测定;微波消解法;电感耦合等离子体质谱;聚类分析

    Investigation and Analysis of Hg Content in 50 Batches of Traditional Chinese Medicine in the Market

    YE Jing1，MA Changhong1，ZHAO Longshan2

    (1 Panjin Center for Inspection and Testing，Panjin 124010，China; 2 College of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016，China)

    Abstract Objective：To determine the content of Hg element in traditional Chinese medicine (TCM) in different varieties and batches to provide a basis for the limited control and market supervision of Hg element in TCM.Methods：The samples were dissolved with microwave digestion.The matrix effect was corrected by the addition of internal standard Bi.ICP-MS was applied to determine the contents of Hg element in TCM for different batches in 11 varieties.SPSS software was applied to the cluster analysis.Results：The Hg element had a good linear relationship (r≥0.999 0).The limit of detection was 0.006 μg/L and the average recovery rate was 100.9% with a 1.9% RSD.RSD values of the repeatability and precision were 1.06% and 2.48% ......