张芹 奥婷 肖淑英

    [摘要] 缺血性脑血管病是常见的慢性致残性疾病，严重影响患者生活质量。研究表明，表皮生长因子受体-细胞外信号调节激酶(EGFR-ERK)通路在缺血性脑血管病的病理生理过程中发挥了重要的作用，但具体机制不详。因此，本文对该通路在缺血性脑血管病中的相关研究进展作一综述，为缺血性脑血管病的进一步基础研究及临床治疗提供参考。

    [关键词] 表皮生长因子受体；细胞外信号调节激酶；EGFR-ERK信号通路；缺血性脑血管病

    [中图分类号] R743 [文献标识码] A [文章编号] 1673-7210(2018)03(c)-0036-05

    [Abstract] Ischemic cerebrovascular disease (ICD) is a common chronic disabling disease. This disease seriously affects the quality of lives of patients. The research shows that the epidermal growth factor receptor-extracellular signal regulated kinase (EGFR-ERK) pathway plays an important role on the pathophysiology process in ICD. However， the mechanism is still unclear. This article reviews the progress of the EGFR-ERK pathway in ICD， which provides references for further basic research and clinical treatment of ICD.

    [Key words] Epidermal growth factor receptor； Extracellular signal-regulated kinase； EGFR-ERK signaling pathway； Ischemic cerebrovascular disease

    缺血性腦血管病具有发病率高、致死率高、致残率高、复发率高等特点，给社会和家庭带来沉重的经济负担和精神负担[1]，是当前世界范围高度重视的公共卫生问题。其病理生理过程复杂[2]，涉及氧自由基的积累、炎症、细胞坏死和凋亡等多个环节。研究表明 ......