郝帅 田武国 高博 何渝军 罗东林

    [摘要] 乳腺癌是女性最常见的恶性肿瘤之一，并且是癌症致死的主要原因。肿瘤在发生发展过程中会持续释放肿瘤细胞DNA入血，这些循环肿瘤DNA(ctDNA)携带肿瘤相关的基因突变信息，使其成为潜在的癌症生物标志物。ctDNA检测作为液体活检的一种，简单易行，能够以微创的方法动态监测肿瘤进展和治疗反应，在乳腺癌领域得到广泛研究，在疾病疗效监测、耐药识别、预测复发、判断预后等方面具有潜在的临床应用价值。

    [关键词] 乳腺癌;循环肿瘤DNA;液体活检

    [中图分类号] R473.73? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)07(c)-0043-04

    Application Progress of circulating tumor DNA in the treatment of breast cancer

    HAO Shuai? ?TIAN Wuguo? ?GAO Bo? ?HE Yujun? ?LUO Donglin

    Department of Breast， Thyroid Surgery， Research Institute of Surgery， Daping Hospital， Army Military Medical University， Chongqing? ?400042， China

    [Abstract] Breast cancer is one of the most common malignant tumors in women and the leading cause of death from cancer. Tumor cell DNA is continuously released into the blood during the development of tumor. These circulating tumor DNA (ctDNA) carry the information of tumor-related gene mutation， making it a potential cancer biomarker. As a kind of liquid biopsy， ctDNA detection is simple and easy， and can dynamically monitor tumor progression and treatment response with minimally invasive methods. It has been widely studied in the field of breast cancer ......