王素 李一平 谢宁

    [摘要] 阿尔茨海默病(AD)是目前最常见的老年痴呆症之一。AD以大脑β淀粉样蛋白沉积形成老年斑，Tau蛋白过度磷酸化造成神经纤维缠结以及神经元丢失等为主要病理表现，并伴有神经炎性改变和认知障碍。现已有广泛研究证明突触功能障碍和突触丢失是AD早期出现的病理表现，Aβ寡聚体对突触有直接毒性作用，但Aβ是通过何种信号通路对突触产生影响亟待进一步研究。Wnt/β-catenin信号通路借助Wnt-LRP6共同位点在成人大脑突触连接的功能和形态完整上起到重要的作用。本文以此為基础挖掘AD患者易感性的潜在机制，以揭示出新的治疗靶点和方法。

    [关键词] 经典wnt信号通路;低密度脂蛋白受体相关蛋白6;Wnt受体拮抗剂;阿尔茨海默病;突触功能;研究进展

    [中图分类号] R34? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)03(b)-0033-04

    [Abstract] Alzheimer′s disease (AD) is one of the most common dementias currently. AD is characterized by the formation of senile plaques by the deposition of β amyloid in the brain， and the main pathological manifestations of neurofibrillary tangles and loss of neurons caused by excessive phosphorylation of Tau protein， accompanied by neuroinflammatory changes and cognitive impairment. There have been extensive studies to prove that synaptic dysfunction and synaptic loss are pathological manifestations of AD in the early stage. Aβ has direct toxic effect on the synapse， but the type of signaling pathway through which Aβ affects the synapse needs further study. The Wnt/β-catenin signaling pathway plays an important role in the functional and morphological integrity of synaptic connections in the adult brain through the common wnt-lrp6 locus. On this basis ......