【摘要】 目的 探讨不均等加速放疗配合甲氨蝶呤增敏治疗食管鳞癌的治疗效果。方法 回顾分析48例确诊为食管鳞癌患者的随访资料。放疗方案:先设前后野照射DT40～44 Gy，后改为等中心照射缩野躲开脊髓加量24～28 Gy，具体分割方法为：周一至周五上午，常规分割剂量(2 Gy)1次/d；周一、三、五下午，与上午放疗间隔>6 h，分割剂量1.5 Gy。化疗方案：每周2次静脉推注甲氨蝶呤50 mg，共3周。结果 1、3、5年的局部控制率和生存率分别为：80.8%、54.9%、39.6%和71%、42.6%、30.7%。结论 不均等加速放疗配合甲氨蝶呤增敏治疗食管鳞癌的治疗方法是可行的。

    【Abstract】 Objective To evaluate the curative effect ofmethotrexate and heterogeneous acceleratedhyperfraction radiotherapy for advanced cancer of esophagus.Methods 48 patients with advanced cancer of esophagus were analyzed.The patients were irradiated with anteroposterior(AP)and posteroanterior(PA)fields to a dose of 40-44 Gy followed by a boost of 24-28 Gy through oblique fields in order to escape the spinal cord.Every patients were irradiated by routine fraction(2Gy once daily ......