【摘 要】目的探讨不同基质金属蛋白酶在动脉硬化兔模型的动态变化。方法 高脂喂食加球囊拉伤股动脉建立动脉硬化兔模型，分别于拉伤后1、7、14、21、28 d采血，ELISA法检测MMP-1、2、8、9，TIMP-1，绘制MMPs动态变化曲线，并取血管行病理检查。结果 MMP-1、9，TIMP-1在拉伤后1 d均达到峰值，延续至拉伤后7 d；三者衍变曲线相似，且有相关性；MMP-2、8在各采血点无差异。结论 MMP-1、9，TIMP-1的动态变化规律可为研究动脉硬化不稳定斑块提供依据。

    【关键词】 基质金属蛋白酶；动脉硬化；兔；动态

    Dynamic changes of matrix metalloproteinses in atherosclerosis rabbit modelCHEN Jun, XU Zhao-yan. The First people′s Hospital of Feshan City, Guangdong Province, Feshan 528333, China

    【Abstract】 Objective To search the dynamic changes of the matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases-1 (TIMP-1) of the atherosclerosis rabbit model.Methods Atherosclerosis models of rabbits were established through high lipid diet and injured femoral arteries by dilated balloon ......