【摘要】 目的 观察经鼻持续气道正压通气(nCPAP)治疗对老年高血压病合并中重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血小板活性及P选择素的影响。方法 入选老年高血压病合并中重度OSAHS患者45例，按患者意愿及对nCPAP耐受情况，分为nCPAP治疗组及对照组，检测治疗前及治疗30 d后血小板活性和P.选择素水平。结果 nCPAP治疗30 d后血清血小板活性和P.选择素较治疗前显著下降(P0.05)。结论 nCPAP治疗可降低老年高血压病合并中重度OSAHS患者血小板活性及P.选择素水平。

    【关键词】 阻塞性睡眠呼吸暂停低通气综合征；高血压病；血小板活性；P选择素

    The effectofnCPAP treatment on platelets activity and P.selectin in elderly coronary heart disease patients with OSAHS PU Juan.juan，LI Tao，OUYANG Song.yun，et al.Department of Geriatrics，The First Affiliated Hospital of Zhenzhou University.Zhenzhou,450052，China

    【Abstract】 Objective To investigate the effect of nasal continuous positive airway pressure(nCPAP)treatment on platelets activity and P.selectin in elderly hypertension patients with moderate or severe obstructive sleep apnea.hypopnea syndrome(OSAHS).Methods 45 elderly hypertension patients with moderate or severe OSAHS were divided into two groups:nCPAP treatment group and control group.The platelet aggression(PAG)and P.selectin were tested on the time of pretreatment ......