[摘要] 目的 比较艾司西酞普兰与氟西汀治疗抑郁症的疗效和安全性。方法 随机将77例符合CCMD—3抑郁发作的住院患者分为艾司西酞普兰组和氟西汀组，艾司西酞普兰组剂量10～20 mg/d，氟西汀组20～40 mg/d，疗程6周。疗效采取汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定，不良反应和安全性用TESS和实验室检查评定。结果 两组总体疗效相当，艾司西酞普兰组有效率为87.2%，治愈率为48.7%，氟西汀组有效率86.8%，治愈率47.4%，两组疗效比较差异无显著性。但1周末时HAMD评分及减分率两组间差异有显著性，说明艾司西酞普兰起效快；艾司西酞普兰组不良反应发生率明显少于氟西汀组，差异有统计学意义。结论 艾司西酞普兰是安全、有效的抗抑郁药。

    A controlled study on the treatment of depression with escitalopram and Fluoxetine

    XU Fu-lian.The Third Peopl’s Hospital of Jiangmen City of Guangdong Province, Jiangmen 52900,China

    【Abstract】Objective To study the efficacy and safety of escitalopram in the treatment of depression.Methods 77 patients who met CCMD-3 criterion for depression episode were randomly assigned to escitalopram group(n=39) with 10-20 mg per day and Fluoxetine group(n=38) with 20-40 mg per day for the treatment of6 weeks. Clinical effectiveness was evaluated using HAMD and HAMA,and adverse reactions and safety were assessed with TESS and laboratory exam ination.Results There was no significant difference of the efficacy between two groups (P>0.05). The response rate and rem ission rate were 87.2% and 48.7% for escitalopram group and were 86.8% and 47.42% for Fluoxetine group respectively. Escitalopram showed rapider efficacy and less side effects than Fluoxetine(P<0.05).Conclusion Escitalopram is an effective and safe antidepressant. ......