肝硬化患者血清瘦素水平的变化及其意义(1)
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【摘要】 目的 测定肝硬化患者血清瘦素水平，并探讨其在肝硬化发病过程中的意义。方法 采用放射免疫法测定56例肝硬化患者和30例对照者血清瘦素和肝纤维化血清学指标：透明质酸(HA)、Ⅳ 型胶原(Ⅳ-C)和层粘蛋白(LN)的水平，同时做肝脏病理活检。结果 肝硬化患者的血清瘦素水平和HA、Ⅳ-C、LN均显著高于对照组(P<0.01)，且瘦素水平与Child-Pugh分级有关(P<0.01)，和HA、Ⅳ-C、LN呈正相关(P<0.01)。结论 肝硬化患者的血清瘦素水平明显升高，其可能与肝纤维化的发展相关。
【关键词】肝硬化；瘦素；肝纤维化
Significance of the serum leptin levels in patients with liver cirrhosis
SUN Li-Hua，SUN zhen, Department of Infection Diseases, Affiliated Hospital of Xinxiang Medical University, Weihui ,Henan 453100, China
【Abstract】 Objective To explore the serum lepfn levels and significance in patients With liver cirrhozis. Methods 56 patients with liver cirrhosis and 30 controlled healthy persons were enlisted in the study. Serum leptin and serological markers of liver fibrosis as hyaluronic acid(HA), type IV collagen(IV-C) ......
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