【摘要】 目的 观察埃索美拉唑联合莫沙必利治疗反流性食管炎的疗效。方法 将90例患者随机分为治疗组(45例)和对照组(45例)。治疗组:埃索美拉唑40 mg, 1次/d;莫沙必利5 mg, 3次/d口服。对照组:埃索美拉唑40 mg, 1次/d口服。治疗前及治疗后2、4、6周计算患者症状积分。治疗后6周复查胃镜,观察胃镜下愈合率。结果 治疗组临床有效率为100%,内镜下有效率为97.8%;对照组分别为86.7%和84.4%,两组比较差异有显著性( P<0.05)。结论 埃索美拉唑联合莫沙必利治疗反流性食管炎比单用埃索美拉唑具有更好的疗效。

    【关键词】埃索美拉唑;莫沙必利;反流性食管炎

    Esomeprazole combined with mosapride therapy for 90 cases of reflux esophagitis

    JIANG Han-long,ZHONG Shi-shun,JIN Feng,et al. Department of Gastroenterology,the 476th Clinical Branch of PLA,Fuzhou 350002,China

    【Abstract】 Objective To study the effect of esomeprazole and mosapride on treatment of reflux esophagitis (RE).Methods 90 RE patients were randomly divided into two groups, the treatment group (45 cases):5 mg of mosapride tid, 20 mg of esomeprazole qd were taken orally; the control group (45 cases):20 mg esomeprazole qd were taken orally.The symptoms were evaluated from pretreatment to every two weeks after the treatment.The endoscope findings at the end of 6 weeks were recheched.Results The clinical curative rates were 100% in the treatment group and 86.7% in the control group, the efficient rate evaluation under endoscope were 97.8%, 84.4% respectively. There was significant difference between the two groups ( P<0.05). Conclusion The effect of esomeprazole combined with mosapride on treating the reflux esophagitis was obviously superior to the other group. ......