蛋白琥珀酸铁口服溶液中的铁含量测定
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【摘要】 目的 测定蛋白琥珀酸铁口服溶液中的铁含量。方法 先用强酸将蛋白琥珀酸铁破坏,使三价铁离子[Fe(Ⅲ)]游离,用还原剂将Fe(Ⅲ)还原为二价铁离子[Fe(Ⅱ)],Fe(Ⅱ)与2,2’-联吡啶溶液形成红色的2,2’ -联吡啶络合物[Fe(CH8N2)3]Cl2,利用比色法测定铁含量。结果 2,2’ -联吡啶络合物在波长525nm处有最大吸收,Fe(Ⅱ)浓度在24.99～149.94μg/ml范围内服从Beer定律,标准曲线回归方程为:Y=0.0065X-0.0279,相关系数r=0.9991,变异系数0.60%,回收率98.86%～100.02%。结论 本方法操作简便、快速、准确,可以用于蛋白琥珀酸铁口服溶液中铁含量的测定。
【关键词】蛋白琥珀酸铁口服溶液;铁含量;2,2’-联吡啶;比色法
Determination of iron in Iron Proteinsuccinylate Oral Solution
LU xiao-ping,YE xin-wu,WANG lin,HANG xia-qing. Jiangsu Jumpcan Pharmaceutical Co., Ltd. 225321,China
【Abstract】 Objective To determine the content of iron in Iron Proteinsuccinylate Oral Solution.Methods Fe(Ⅲ) was dissociated by destruction of Iron Proteinsuccinylate using strong acid firstly, then Fe(Ⅲ) was reduced to Fe(Ⅱ) by reductant. The mixture of Fe(Ⅱ) and 2,2’-bipyridine solution led to the red complex 2,2’-bipyridine[Fe(CH8N2)3]Cl2,and the content of iron was determined by colorimetric method ......
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