796例泌尿生殖道支原体培养及药敏分析(1)
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【摘要】 目的 探讨我院泌尿生殖道感染患者支原体感染情况,分析其对抗生素的敏感性。方法 采用珠海市丽珠试剂股份有限公司生产的支原体培养、鉴定、药敏一体化试剂盒,对796例泌尿生殖道感染患者的分泌物标本进行支原体培养鉴定,并同时进行9种抗菌药物的体外药物敏感试验。结果 796例标本中支原体感染率为32.3%,男性感染率为11.4%,女性感染率为45.3%;其中解脲脲原体(Uu)阳性234例(占29.3%),人型支原体(Mh)阳性9例(占1.2%),Uu+Mh混合感染阳性14例(占1.8%)。支原体药物敏感试验显示,Uu对氧氟沙星、司帕沙星、左氧氟沙星的耐药率分别为23.1%、18.0%、14.1%(P<0.05),Uu+Mh对上述药物的耐药率分别为57.1%、28.6%、28.5%(P<0.05)。强力霉素、交沙霉素、美满霉素、克拉霉素有较强的抗菌能力。结论 支原体的耐药性在不同地区表现不同,临床应参照药敏试验结果选用抗菌药治疗患者。
【关键词】 支原体;感染;耐药性
796 cases of genitourinary tract mycoplasma cultivation and antibiotic sensitivity analysis
LIN Wen-zhen,LI Yue-chan,LIANG Jing-xin.
The fifth Afflitased Hospital of Sun Yat-Sen University,Zhuhai,519000,China
【Abstract】 Objective To investigate the prevalence and antibiotic susceptibility of genital mycoplasma infection in the local area.Methods To detect mycoplasma and their drug sensitivity with culture method.Results The infectious rates of mycoplasma among 796 STD high-risk population were32.3%, from then rates were in men 11.4%, and were in women were 45.3%. Among these pat-ients positive UU and positive Mh were found in 234 patients(29.3 %), 9 patients (1.2%) respect-ively.And the mixed infection by Mycoplasma hominis (Mh) and Ureaplama urealyticum (Uu) were 14 cases(1.8%) respectively.Resistance of Uu to Ofloxacin,Sparfloxacin and Levofloxacin were 23.1%,18.0% and 14.1%,respectively.Resistance to Ofloxacin,Sparfloxacin and Levofloxacin in both Uu and Mh isolate were 57.1%,28.6%and28.5%,respectively.Doxycycline,Josamycin,Minocycline and Clarithromycin had the higher bacteriostaic ability. Conclusion The antibiotic resistance of myco-plasma is diffetent in vary areas,must be refereneed of antibiotic susceptibility test results before to select proper drugs for treatment.
【Key words】 Mycoplasma; Infection; Reistance
作者单位:519000中山大学附属第五医院
支原体是一种介于细菌和病毒之间,能在人工培养基上生长繁殖的原核细胞型微生物。支原体中的解脲脲原体(ureaplasma urealyticum,UU)和人型支原体(mycoplasma hominis,Mh)是泌尿生殖道感染常见的病原体之一,它可引起非淋菌性尿道炎,盆腔感染性疾病等,也可诱发早产、自然流产和低体重儿等病症[1,2]。临床治疗以抗生素为主,随着抗生素的大量使用和支原体感染的普遍增多,其对常用抗生素的耐药性也在增加,且不同地区也表现出不同的耐药特征[3]。如何合理应用抗生素,防止耐药性的产生,控制其感染是一个亟待解决的问题,为此,我们对2009年1月至2009年12月检测的来自珠海市及其周边地区的796例患者的检测及药敏结果进行了分析 ......
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