论文下载：正常男性体重指数与睾酮和雌二醇关系的探讨

正常男性体重指数与睾酮和雌二醇关系的探讨(1)

http://www.100md.com 2010年11月25日陈维真彭其才罗辉

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     【摘要】目的探讨正常男性体重指数(BMI)与睾酮(T)、雌二醇(E2)的关系。方法收集因不孕症就诊的夫妻中男性正常者43例,检测其BMI和血清T、E2水平。结果 43例男性的平均BMI 296 kg/m2。有生育史的男性的BMI(267 ±61)kg/m2明显低于无生育史的男性的BMI(317±53)kg/m2(P<001)。有生育史的男性的血清T水平(191±41)nmol/L明显高于无生育史的男性的血清T水平(167±31)nmol/L(P<005)。有生育史的男性的血清E2水平(792±242)pmol/L明显低于无生育史的男性的血清E2水平(1053±247)pmol/L(P<001)。BMI与血清T水平成负相关(r=0807,P<0001),与血清E2水平成正相关(r=0684,P<0001)。结论 BMI的增加是男性生育力下降的影响因素之一。

    【关键词】

    男性;体重指数;睾酮;雌二醇

    The association of BMI and testosterone and estradiol in normal men

    CHEN Weizhen, PENG Qicai, LUO Hui

    Department of Nuclear Medicine, Department of Obstetrics & Gynecology,the Third Affiliated Hospital of Sun Yatsen University, Guangzhou 510630, China

    

    【Abstract】 Objective To explore the association of body mass index (BMI) and serum testosterone (T) and estradiol (E2) in normal men Methods There were total 43 cases of normal men who were seeking fertility assistance Their BMI, serum testosterone and estradiol was measured Results The mean BMI of 43 men was 296 kg/m2.BMI in male with paternity (267±61)kg/m2 was lower than that of male without (317±53)kg/m2(P<001) Serum T level in male with paternity (191±41)nmol/L was higher than that of male without (167±31)nmol/L(P<005 Serum E2 level in male with paternity (792±242)pmol/L was lower than that of male without (1053±247)pmol/L) (P<001) BMI was negatively correlated with serum T level (r=0807, P<0001), while positively correlated with serum E2 level (r=0684, P<0001)Conclusion The increase of BMI maybe one of the risk factors of decreased male fertility

    【Key words】

    Male;Body index mass;Testosterone;Estradiol

    在所有不孕症患者者,约有半数是男性因素导致的[1]。因不孕症就诊的男性中有40%是肥胖患者[2]。肥胖的不孕症男性患者比非肥胖的不孕症男性患者的睾酮、性激素结合球蛋白、睾酮/雌二醇比值均低[3]。但是非不孕症的肥胖男性的生育能力却研究的甚少。本研究通过探讨正常男性BMI与血清睾酮和雌二醇的关系,以研究超重和肥胖对正常男性生育能力的影响。

    1 材料和方法

    11 临床资料收集因不孕症就诊的夫妻中,男方正常的患者43例,年龄22~45岁,平均343岁。所有受检者均经系统检查提示男方的生育能力基本正常。

    12 方法

    121 体重指数测定

    所有受检者均检测身高、体重,计算体重指数(body mass index,BMI)=体重/身高2(kg /m2)。

    122血清T、E2水平检测

    所有受检者于清晨空腹抽取静脉血3 ml,采用西门子ADVIA Centaur CP全自动化学发光免疫分析仪和配套试剂检测血清睾酮(Testosterone,T)和雌 ......

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