分娩镇痛对产妇T细胞亚群的影响(2)
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在本研究中,皮质醇在T2时点两组有明显差异,在T3时点趋于一致,可能是分娩结束及疼痛应激解除的原因,另外也可能与皮质醇的半衰期短(约60 min)有关。T细胞亚群在T1、T2时间点无明显变化,而在分娩后24 h表现为显著下降,这可能与效应淋巴细胞的寿命约1周有关。本研究只看到T细胞亚群下降趋势,没有显示开始回升至正常的时间,是本研究的缺憾之处。因产妇住院周期短,分娩后第1、2天就出院,要延长观察时间有客观困难。
从以上分析可看出,分娩剧痛可使机体的免疫功能受到一定的影响,而CSEA分娩镇痛能较好地抑制疼痛引起的应激反应,对母体的免疫功能具有一定的保护作用,且对产程和新生儿Apgar评分无影响。
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