临床研究冻干重组人脑利钠肽治疗慢性充血性心力衰竭的疗效观察(1)
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【摘要】 目的 观察冻干重组人脑利钠肽治疗慢性充血性心力衰竭的临床疗效。方法 80例慢性充血性心力衰竭患者随机分为新活素组40例和对照组40例。两组患者均给予标准的抗心力衰竭治疗，新活素组加用冻干重组人脑利钠肽，首次负荷剂量为1.5 μg/kg静脉注射，然后按0.0075 μg/(kg·min)剂量持续静脉泵入，连续用药72 h。观察患者治疗前及治疗后1周的临床症状、血浆中NTproBNP的浓度及左室射血分数(LVEF)等情况。结果 新活素组的治疗总有效率显著优于对照组(P<0.01)。新活素组治疗1周后各项指标的变化较对照组明显改善(P<0.05)。结论 冻干重组人脑利钠肽治疗慢性充血性心力衰竭，可以降低血浆中NTproBNP的浓度，显著改善患者的临床症状和心功能。
【关键词】
冻干重组人脑利钠肽；慢性充血性心力衰竭；NTproBNP；LVEF
Curative effect of recombinant human brain natriuretic peptide on treating chronic congestive heart failure
TIAN Zhipeng.
Department of Cardiovasology, FengtianHospital of Shenyang Medical College, Liaoning 110024, China
【Abstract】 Objective To explore the clinical curative effect of recombinant human brain natriuretic peptide in chronic congestive heart failure. Methods Eighty patients with chronic congestive heart failure were randomly divided into the Xinhuosu group(40 patients) and the control group (40 patients). The patients in both groups were given standard antiheart failure therapy. The Xinhuosu group was added rhBNP. For the first time loading dose of 1.5 μg/kg intravenous injection, and then press0.0075 μg/(kg·min) dose continuous intravenous pump, continuous medication 72 h. Observed the clinical symptoms, the plasma NTproBNP concentration and left ventricular ejection fraction (LVEF) in patients before and one week after treatment. Results The efficiency and the total effective rate of the Xinhuosu group was significantly better than that of control group(P<0.01). The indexes one week after treatment of the Xinhuosu group changed more significantly than that of the control group(P<0.05). Conclusion The rhBNP could significantly improve the clinical symptoms and cardiac function in patients with chronic congestive heart failure and reduce plasma NTproBNP concentration.
【Key words】
Chronic congestive heart failure；Recombinant human brain natriuretic peptide； NTproBNP； LVEF
作者单位：110024辽宁省沈阳医学院奉天医院循环内科
通讯作者：田志鹏 Email：tzply@sina.com
慢性充血性心力衰竭是各种心脏疾病发展的最终归宿，也是临床上最主要的死亡原因。冻干重组人脑利钠肽(新活素)是人工合成的内源性激素，具有扩张血管、利钠利尿、有效降低心脏前后负荷、抑制肾素血管紧张素醛固酮系统和交感神经系统等作用 ......
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