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HPLC法测定酚酞片中酚酞的含量
http://www.100md.com 2011年9月5日 《中国实用医药》 2011年第25期
     【摘要】 目的 建立酚酞片中酚酞含量的测定方法。方法 采用高效液相色谱法,甲醇0.05%磷酸溶液(70:30)为流动相;流速0.8 ml/min;检测波长为275 nm。结果 酚酞在10.00~250.00 mg/L范围内呈良好的线性关系,r=0.9999,平均回收率为100.10%,RSD=0.27%(n=5)。结论 该方法简便、准确、重复性好,能很好地控制酚酞片的质量。

    【关键词】

    高效液相色谱法;酚酞片;含量测定;酚酞

    

    Determination of phenolphthalein in phenolphthalein tablets by HPLC

    SUN Yinhua. Maanshan Institute of Drug Control, Maanshan 243000,China

    

    【Abstract】 Objective

    To establish a method for the determination of phenolphthalein in phenolphthalein tablets Methods The separation was performed on HPLC. The mobile phase was methanolphosophoric acid solution(0.05%)(70:30)at a flow rate of 0.8 ml/min.The detection wavelength was at 275nm. Results The linear of phenolphthalein was in the range of 10.00~250.00 mg/L(r=0.9999). The average recovery was 100.10% and RSD was 0.27% (n=5). Conclusion The method is convenient, accurate and reproducible. It can be suitable for controlling the quality of phenolphthalein tablets. ......

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