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68例葡萄胎的临床病理分析
http://www.100md.com 2011年10月5日 周竞奇
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     【摘要】 目的 探讨葡萄胎的病理特点,提高病理正确诊断率。方法 收集本院2008年1月至2011年6月病理诊断的葡萄胎的患者标本进行病理检查。结果 侵袭性葡萄胎镜下观察:肌层内查见水肿变性的胎盘绒毛组织;部分绒毛水肿变性镜下观察:部分绒毛间质水肿变性, 滋养细胞轻度增生;葡萄胎可疑镜下观察:部分绒毛间质水肿变性, 灶状滋养细胞增生;完全性葡萄胎镜下观察弥漫性绒毛间质水肿, 间质血管减少或消失, 滋养细胞轻、中、重不同程度的增生, 常伴有异型性;部分性葡萄胎镜下观察:部分绒毛间质高度水肿, 间质血管减少或消失, 滋养细胞轻、中不同程度的增生。结论 掌握葡萄胎的肉眼观察和镜下观察特点,结合临床进行分析有助于提高正确诊断率。

    【关键词】 葡萄胎;病理特点;水肿

    68 cases of clinical and pathological analysis of mole ZHOU Jing-qi.Department of pathology,the People’s Hospital of Henan Province,Jiyuan city,Jiyuan 459000,China

    【Abstract】 Objective To investigate the pathological features of mole, the right to improve the pathological diagnosis. Methods The hospital in January 2008-June 2011 in patients with pathological diagnosis of hydatidiform mole specimens for pathological examination.Results Invasive mole were observed: edema and degeneration of muscle within the investigation, see the placenta; part of the villus edema and degeneration were observed: partial villous interstitial edema and degeneration, mild trophoblastic hyperplasia; suspicious mole were observed: interstitial edema and degeneration of some villi, trophoblastic hyperplasia spotty; complete mole were observed diffuse villous interstitial edema, interstitial vascular reduction or disappearance of trophoblastic light, moderate and severe degree of proliferation of different, often accompanied by abnormal sex; partial mole were observed: some villus height interstitial edema, interstitial blood vessels decreased or disappeared, trophoblastic light, in different degrees of proliferation. Conclusion The master of the mole and the naked eye were observed features, combined with analysis to help improve the accuracy of clinical diagnosis.

    【Key words】 Mmole; pathological features;Edema

    葡萄胎是由于妊娠后胎盘绒毛滋养细胞增生和绒毛间质水肿,而形成大小不等的水泡成串相连,状似葡萄得名[1]。分为完全性葡萄胎和部分性葡萄胎。但是由于镜下不典型,很难确诊,为探讨葡萄胎的病理特点,提高正确诊断率,本文收集河南省济源市人民医院2008年1月知2011年6月病理诊断的68例葡萄胎资料进行回顾性分析,现报告如下。

    1 资料与方法

    1.1 一般资料 68例均来自本院2008年1月至011年6月病理诊断的葡萄胎的患者。年龄20~46岁,平均28.6岁,其中20~30岁有49例,占72.1%,有停经史者65例占95.6%,停经的患者中有60例有不规则阴道流血,流血时间最短1 d, 最长39 d, 恶心、呕吐6例,子宫增大与月份不符的患者有16例。停经在2个月内60 d有6例, 2~5个月61例, 1例停经史不祥。本组患者标本来源:子宫切除标本3例 ......

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