胰腺癌中MMP,9和E,cad的表达及意义(1)
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【摘要】 目的 研究MMP,9和E,cad在胰腺癌组织中的表达，并探讨它们的相关性及临床意义。方法 采用免疫组化SP法检测15例正常胰腺组织、30例胰岛素细胞瘤和50例胰腺癌组织中MMP,9和E,cad的表达情况。结果 MMP,9和E,cad在胰腺癌组织中的阳性表达率分别为82%、24%；MMP,9为高表达，E,cad为低表达，MMP,9和E,cad蛋白的表达与有无淋巴结转移和分化程度相关(P<0.05)；两种蛋白在胰腺癌组织中的表达呈负相关(P<0.05)。结论 MMP,9和E,cad在肿瘤侵袭转移中发挥了重要作用，检测MMP,9和E,cad的表达可作为预测胰腺癌的转移趋势指标，并能有效的评估胰腺癌患者的预后。
【关键词】 胰腺癌；上皮钙粘附蛋白；基质金属蛋白酶,9；免疫组化
Expression and clinical significance of matrix met alloproteinase,9 and E,cadherin in pancreatic cancer HUANG Xiang,wu,CHEN Zhi,qing,LIN Fang,yin,et al.Department of Pathology and General Surgery,Affiliated Hospital of Putian College,Fujian 351100,China
【Abstract】 Objective To observe the expression and of matrix met alloproteinase 9 protein (MMP,9) and E,cadherin protein (E,cad) in pancreatic cancer, and to investigate the correlation and clinical significance of MMP,9 and E,cad proteins expression. Methods Expression of MMP,9 and E,cad in 15 normal tissue specimens,30 specimens of Insulinoma and 50 specimens of pancreatic cancer was determined by immunohistochemical staining，and relationship between MMP,9 and E,cad expression and pathological features in pancreatic cancer.Results The positive rate of MMP,9 and E,cad 82%,24%.The expression of MMP,9 and in the tissue of pancreatic cancer was significantly higher than that in Insulinoma and normal pancreas.The expression of E,cad in the tissue of pancreatic cancer was significantly lower than that in Insulinoma and normal pancreas(P<0.05).The expression of MMP,9 and E,cad protein was associated with lymphatic metastasis and pathological types (P<0.05). The expression of MMP,9 and E,cad protein were negative correlated in pancreatic cancer (P<0.05).Conclusion MMP,9 and E,cad proteins play a critical role in tumor metastasis.Co,detection of the expression of MMP,9 and E,cad can be used to predict the metastatic potential of Pancreatic Cancer, and can effectively evaluate the prognosis of patients with pancreatic cancer.
【Key words】 Pancreatic cancer; E,cad;MMP,9; Immunohistochemistry ......
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