吉林地区妊娠妇女糖耐量水平的调查研究(1)
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【摘要】 目的 了解吉林地区妇女正常妊娠、妊娠糖耐量受损、妊娠糖尿病的糖耐量水平。方法 4家医院联合前瞻性对1987名孕妇在孕24~32周间先行50 g糖筛查试验,不管其值高低均于3 d后行口服葡萄糖耐量试验(OGTT)。结果 OGTT按美国国家糖尿病资料组(NDDG)标准判断正常组1153名,取其4次血糖值的第97.5百分位数为5.36、9.62、6.58和6.82 mmol/L。OGTT中1项异常或2 h血糖值在6.67~9.11 mmol/L之间为GIGT组751名,第97.5百分位数血糖值为6.11、11.90、9.59、和8.02 mmol/L。GDM组83例,其中72例根据OGTT 4项值中≥2项异常确诊,其血糖值为8.02、16.88、14.42和11.70 mmol/L。结论 吉林地区正常孕妇OGTT第97.5百分位数的血糖值略低于国内外报道。目前应用的NDDG诊断标准是否过高导致假阴性,有待进一步调查研究。
【关键词】
妊娠糖尿病; 口服葡萄糖耐量试验
The investigate the glucose tolerance level among pregnant women in Jilin.
TIAN Xin.
Department of Gynaecology and Obstertrics,The People’s Hospital of Jilin City,Jilin 132001,China
【Abstract】 Objective
To investigate the glucose tolerance level among pregnant women in jilin. Methods After 50 g glucose challenge test (GCT) was done, a prospective study of 75 g oral glucose tolerance test (OGTT) in 1987 pregnant women between 24~32 gestational weeks was done in four hospitals so as to investigate the glucose tolerance levels in normal, GIGT, GDM women. Results By the judgment of diagnostic criteria of NDDG, 1153patients OGTT were normal. The 97.5th percentage of their plasma glucose level (mmol/L) were 5.36,9.62,6.58 and 6.82 mmol/L. The 751 GIGT patients were diagnosed by OGTT, the glucose levels were 6.11,11.90,9.59 and 8.02 mmol/L. 83 patients were GDM and 72 of them were diagnosed by OGTT. Their plasma glucose levels in 97.5 thpercentage were 8.02,16.88,14.42 and 11.70 mmol/L. Conclusion The 97.5thpercentages of OGTT in normal pregnant women in Jilin region are lower in our study than those in domestic and international reports. It needs further research to determine if the present NDDG diagnostic standard are too high so that it will increase false negative rate.
【Key words】
Gestational diabetes mellitus; Glucose tolerance test
作者单位：132001吉林市人民医院妇产科
妊娠糖尿病(gestational diabetes mellitus GDM) 是指在妊娠期首次发生或发现的糖代谢异常，其对孕妇、胎儿与婴儿的近期和远期影响已为人们所关注，但有关他的诊断标准国际国内尚未完全统一。由于人体对糖负荷的耐受程度受多种因素影响，不同国家、地区、种族等可能有不同的差别，本研究调查了吉林地区妊娠妇女的糖耐量水平。
1 资料与方法
1.1 一般资料 2009年1月至2010年12月北华大学附属医院、吉林市中心医院、吉林市第二中心医院及吉林市妇产医院四家医院妇产科门诊共2152名24~32周的孕妇(其中不包括孕前糖尿病患者)进行以下系列血糖测定,并填写统一的调查表 ......
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