高糖中膀胱ICCs超微结构的变化(2)
研究结果显示， ICCs功能及其结构的变化与高浓度糖的内环境有密切关系。内环境中糖浓度的升高、作用的时间长，则ICCs细胞结构及功能变化也就更明显。由此推测：高浓度糖破坏ICCs细胞的超微结构、胞突消失，造成该类细胞的起搏和传递中介的功能、结构变化，导致膀胱兴奋能力变化，膀胱逼尿肌舒缩能力产生变化，而使DCP临床症状出现。高糖中ICCs细胞的超微结构被破坏有可能是临床发生DCP的病理基础之一。
参 考 文 献
[1] Jiang HH, SongB, Lu GS, et al. Loss of ryanodine receptor calcium release channel expression associated with overactive urinary bladder smooth muscle contractions in adetrusor instability model. BJU Int,2005,96 (3):428-433.
[2] Andersson KE, Arner A. Urinary bladder contraction and relaxation;physiology and pathophysiology. Physiol Rev,2004,84:935-986.
[3] McCloskey KD. Characterization of outward currents in interstitial cells from the guinea pig bladder.J Urol,2005,173：(1):296-301.
[4] Davidson R A, McCloskey KD. Morphology and localization of interstitial cells in the guinea pig bladder:structural relationships with smooth muscle and neurons. J Urol, 2005,173(4):1385-1390.
[5] McCloskey KD, Gurney AM. Kit positive cells in the guinea pig bladder. J Urol, 2002,168(2):832-836.
[6] Exintaris B, Klemm MF, Lang RJ. Spontaneous slow wave and ontractile activity of the guinea pig prostate., J Urol,2002,168(1):315-322., 百拇医药(范勇洪)
参 考 文 献
[1] Jiang HH, SongB, Lu GS, et al. Loss of ryanodine receptor calcium release channel expression associated with overactive urinary bladder smooth muscle contractions in adetrusor instability model. BJU Int,2005,96 (3):428-433.
[2] Andersson KE, Arner A. Urinary bladder contraction and relaxation;physiology and pathophysiology. Physiol Rev,2004,84:935-986.
[3] McCloskey KD. Characterization of outward currents in interstitial cells from the guinea pig bladder.J Urol,2005,173：(1):296-301.
[4] Davidson R A, McCloskey KD. Morphology and localization of interstitial cells in the guinea pig bladder:structural relationships with smooth muscle and neurons. J Urol, 2005,173(4):1385-1390.
[5] McCloskey KD, Gurney AM. Kit positive cells in the guinea pig bladder. J Urol, 2002,168(2):832-836.
[6] Exintaris B, Klemm MF, Lang RJ. Spontaneous slow wave and ontractile activity of the guinea pig prostate., J Urol,2002,168(1):315-322., 百拇医药(范勇洪)