温胆汤加味联合黛力新治疗难治性功能性消化不良伴睡眠障碍的效果观察(1)
【摘要】 目的 探討分析温胆汤加味联合氟哌噻吨美利曲辛片(黛力新)治疗难治性功能性消化不良伴睡眠障碍的临床效果。方法 80例难治性功能性消化不良伴睡眠障碍患者， 随机分为中药治疗组以及参照组， 每组40例。参照组给予莫沙必利联合黛力新治疗， 中药治疗组给予温胆汤加味联合黛力新治疗。实验结束后， 对比分析两组患者治疗前后的症状评分、临床疗效以及不良反应发生情况。结果 治疗前两组患者症状评分比较差异无统计学意义(P>0.05)；治疗后中药治疗组症状评分低于参照组， 差异具有统计学意义(P<0.01)。中药治疗组治疗总有效率为97.5%， 参照组治疗总有效率为82.5%， 中药治疗组总有效率高于参照组， 差异具有统计学意义(P<0.05)。中药治疗组不良反应发生率为5.0%， 参照组不良反应发生率为20.0%， 中药治疗组不良反应发生率低于参照组， 差异具有统计学意义(P<0.05)。结论 温胆汤加味联合黛力新治疗难治性功能性消化不良伴睡眠障碍可取得显著的治疗效果， 其疗效持久， 安全性较高， 不良反应较少， 值得临床推广应用。
【关键词】 温胆汤加味；氟哌噻吨美利曲辛片；难治性功能性消化不良；睡眠障碍；临床效果
DOI：10.14163/j.cnki.11-5547/r.2017.16.008
Observation on effect of modified Wendan decoction combined with Deanxit in the treatment of refractory functional dyspepsia complicated with sleep disorders LIU Yan-min， CEHN Min， FU Dao-shi. Guangzhou City Huangpu District Science and Technology Bureau， Guangzhou 510760， China
【Abstract】 Objective To explore and analyze the clinical effect of modified Wendan decoction combined with flupentixol and melitracen tablets (Deanxit) in the treatment of refractory functional dyspepsia complicated with sleep disorders. Methods A total of 80 patients with refractory functional dyspepsia and sleep disorders were randomly divided into traditional Chinese medicine treatment group and control group， with 40 cases in each group. The control group received mosapride combined with Deanxit for treatment， and the traditional Chinese medicine treatment group received modified Wendan decoction combined with Deanxit for treatment. After experiment， comparison and analysis were made on symptom score before and after treatment， clinical curative effect and adverse reactions occurrence in two groups. Results Before treatment， both groups had no statistically significant difference in symptom score (P>0.05). After treatment， the traditional Chinese medicine treatment group had lower symptom score than the control group， and the difference had statistical significance (P<0.01). The traditional Chinese medicine treatment group had total treatment effective rate as 97.5%， while the control group had total treatment effective rate as 82.5%. The traditional Chinese medicine treatment group had higher total effective rate than the control group， and the difference had statistical significance (P<0.05). The traditional Chinese medicine treatment group had incidence of adverse reactions as 5.0%， while the control group had incidence of adverse reactions as 20.0%. The traditional Chinese medicine treatment group had lower incidence of adverse reactions than the control group， and the difference had statistical significance (P<0.05). Conclusion Combination of modified Wendan decoction and Deanxit shows significant therapeutic effect in treating refractory functional dyspepsia， and it shows lasting curative effect， high safety and few adverse reactions. So it is worthy of clinical popularization and application., 百拇医药(刘艳敏 陈敏 付道时)
【关键词】 温胆汤加味；氟哌噻吨美利曲辛片；难治性功能性消化不良；睡眠障碍；临床效果
DOI：10.14163/j.cnki.11-5547/r.2017.16.008
Observation on effect of modified Wendan decoction combined with Deanxit in the treatment of refractory functional dyspepsia complicated with sleep disorders LIU Yan-min， CEHN Min， FU Dao-shi. Guangzhou City Huangpu District Science and Technology Bureau， Guangzhou 510760， China
【Abstract】 Objective To explore and analyze the clinical effect of modified Wendan decoction combined with flupentixol and melitracen tablets (Deanxit) in the treatment of refractory functional dyspepsia complicated with sleep disorders. Methods A total of 80 patients with refractory functional dyspepsia and sleep disorders were randomly divided into traditional Chinese medicine treatment group and control group， with 40 cases in each group. The control group received mosapride combined with Deanxit for treatment， and the traditional Chinese medicine treatment group received modified Wendan decoction combined with Deanxit for treatment. After experiment， comparison and analysis were made on symptom score before and after treatment， clinical curative effect and adverse reactions occurrence in two groups. Results Before treatment， both groups had no statistically significant difference in symptom score (P>0.05). After treatment， the traditional Chinese medicine treatment group had lower symptom score than the control group， and the difference had statistical significance (P<0.01). The traditional Chinese medicine treatment group had total treatment effective rate as 97.5%， while the control group had total treatment effective rate as 82.5%. The traditional Chinese medicine treatment group had higher total effective rate than the control group， and the difference had statistical significance (P<0.05). The traditional Chinese medicine treatment group had incidence of adverse reactions as 5.0%， while the control group had incidence of adverse reactions as 20.0%. The traditional Chinese medicine treatment group had lower incidence of adverse reactions than the control group， and the difference had statistical significance (P<0.05). Conclusion Combination of modified Wendan decoction and Deanxit shows significant therapeutic effect in treating refractory functional dyspepsia， and it shows lasting curative effect， high safety and few adverse reactions. So it is worthy of clinical popularization and application., 百拇医药(刘艳敏 陈敏 付道时)