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盐酸米诺环素联合布洛芬对慢性牙周炎的疗效观察(1)
http://www.100md.com 2018年1月15日 中国实用医药 2018年第2期
     【摘要】 目的 探讨盐酸米诺环素联合布洛芬对慢性牙周炎的临床疗效。方法 120例慢性牙周炎患者, 随机分成观察组和对照组, 每组60例。两组患者均予以超声洁刮治疗, 对照组使用盐酸米诺环素治疗, 观察组使用盐酸米诺环素联合布洛芬治疗, 比较两组患者治疗效果以及治疗前后的菌斑指数、菌落数量、龈沟出血指数。结果 治疗后, 两组患者的菌斑指数、菌落数量、龈沟出血指数均明显低于治疗前, 观察组患者的菌斑指数、菌落数量、龈沟出血指数明显低于对照组, 差异具有统计学意义(P<0.05)。观察组患者的治疗总有效率为98.3%, 显著高于对照组的85.0%, 差异具有统计学意义(P<0.05)。

    结论 盐酸米诺环素联合布洛芬对慢性牙周炎的疗效明显, 值得推广应用。

    【关键词】 盐酸米诺环素;布洛芬;慢性牙周炎;临床疗效

    DOI:10.14163/j.cnki.11-5547/r.2018.02.048

    Observation of the efficacy of minocycline hydrochloride and ibuprofen in the treatment of chronic periodontitis ZHAO Xue-kui. Department of Stomatology, Shandong Tancheng First People’s Hospital, Linyi 276199, China

    【Abstract】 Objective To discuss the clinical efficacy of minocycline hydrochloride and ibuprofen in the treatment of chronic periodontitis. Methods A total of 120 chronic periodontitis patients were randomly divided into observation group and control group, with 60 cases in each group. Both groups received ultrasonic curettage therapy, and the control group received minocycline hydrochloride for treatment. The observation group received minocycline hydrochloride and ibuprofen for treatment. Comparison were made on treatment effect, plaque index, colony number, gingival bleeding index before and after treatment between two groups. Results After treatment, both groups had obviously lower plaque index, colony number, gingival bleeding index than before treatment, and the observation group had obviously lower plaque index, colony number, gingival bleeding index than the control group. Their difference was statistically significant (P<0.05). The observation group had obviously higher total treatment effective rate as 98.3% than 85.0% in the control group, and the difference was statistically significant (P<0.05). Conclusion Combination of minocycline hydrochloride and ibuprofen provides remarkable efficacy for chronic periodontitis, and is worthy of promotion and application.

    【Key words】 Minocycline hydrochloride; Ibuprofen; Chronic periodontitis; Clinical efficacy

    牙周炎多是由細菌感染引发的口腔疾病, 慢性牙周炎占近95%, 炎症由牙龈不断扩散至牙周膜、牙槽骨、牙骨质发展而成, 进行形成牙周袋、牙周溢脓、牙齿松动等, 对患者的生活造成影响。慢性牙周炎的治疗原则是首先需将菌斑、牙石等诱发因素彻底清除, 进而改善牙龈炎症, 缓解牙周袋症状, 并争取促进牙周组织再生。有研究指出[1]牙周炎可能成为冠心病、糖尿病等系统性疾病危险因素, 全身系统性的疾病同牙周炎也有关联。因此及早改善症状, 促进牙周组织功能康复在口腔治疗中有重要临床意义。抗菌药物治疗是牙周炎治疗的主要方案, 盐酸米诺环素是广谱抗生素, 布洛芬具有抗炎镇痛之效, 本文探讨两者联合应用治疗慢性牙周炎的临床疗效, 现报告如下。

    1 资料与方法

    1. 1 一般资料 选取2015年6月~2017年6月本院收治的120例慢性牙周炎患者作为观察对象, 将其随机分成观察组和对照组, 每组60例。观察组中男36例, 女24例;年龄36~58岁, 平均年龄(48.6±7.2)岁;患牙1~3颗, 平均患牙(1.6±0.5)颗。对照组中男34例, 女26例;年龄37~60岁, 平均年龄(49.2±7.6)岁;患牙1~3颗, 平均患牙(1.7±0.5)颗。两组患者的性别、年龄、患牙数量等一般资料比较差异无统计学意义(P>0.05), 具有可比性。排除严重感染、肝肾功能异常和其他口腔疾病等, 两组患者均自愿接受本次研究, 签署知情同意书。, 百拇医药(赵雪奎)
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