阿司匹林抵抗与冠心病合并2型糖尿病患者MACE的临床关系(1)
【摘要】 目的 探讨阿司匹林抵抗(AR)与冠心病合并2型糖尿病患者不良心血管事件(MACE)发生的关系。方法 120例冠心病合并2型糖尿病患者， 根据是否发生AR分为AR组与非AR组， 比较两组的MACE发生情况， 并根据患者是否发生MACE分为发生组与未发生组， 比较患者的一般资料， 进而分析AR等与冠心病合并2型糖尿病患者发生MACE的关系。结果 AR组MACE发生率51.43%明显高于非AR组的23.53%， 差异具有统计学意义(P<0.05)。发生组性别、收缩压、舒张压、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)水平与未发生组比较差异无统计学意义(P>0.05);发生组年龄、体质量指数(BMI)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)、AR发生情况与未发生组比较差异具有统计学意义(P<0.05)。经Logistic分析分析， 年龄、LDL-C、HbA1c、AR是影响MACE发生的因素(P<0.05)。结论 存在AR的冠心病合并糖尿病患者发生MACE的风险更高， 年龄、LDL-C、HbA1c、AR均是导致MACE发生的危险因素。
【关键词】 阿司匹林抵抗;2型糖尿病;不良心血管事件;冠心病
DOI：10.14163/j.cnki.11-5547/r.2018.12.002
【Abstract】 Objective To investigate the relationship between aspirin resistance (AR) and main adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus complicated with coronary heart disease. Methods A total of 120 patients with type 2 diabetes mellitus complicated with coronary heart disease were divided by occurrence of AR into AR group and non-AR group. The occurrence of MACE in the two groups was compared， and the patients were divided by occurrence of MACE into the occurrence group and non-occurrence group. The general data of patients was compared， and then the relationship between AR and MACE in patients with coronary heart disease and type 2 diabetes mellitus was analyzed. Results AR group had obviously higher incidence of MACE as 51.43% than 23.53% in non-AR group， and the difference was statistically significant (P<0.05). The occurrence group had no statistically significant difference in gender， systolic blood pressure， diastolic blood pressure， total cholesterol (TC)， high density lipoprotein cholesterol (HDL-C)， and fasting blood glucose (FBG) level， comparing with non-occurrence group (P>0.05). The occurrence group had statistically significant difference in age， body mass index (BMI)， triglyceride (TG)， low density lipoprotein cholesterol (LDL-C)， glycosylated hemoglobin (HbA1c) and AR occurrence， comparing with non-occurrence group (P<0.05). According to Logistic analysis， age， LDL-C， HbA1c and AR were factors affecting the occurrence of MACE (P<0.05). Conclusion There is a higher risk of MACE in patients with coronary heart disease and diabetes mellitus who have AR. Age， LDL-C， HbA1c and AR are all risk factors for the occurrence of MACE.
【Key words】 Aspirin resistance; Type 2 diabetes mellitus; Main adverse cardiovascular events; Coronary heart disease
多數冠心病患者合并有2型糖尿病， 二者常互为因果， 加重患者的病情， 增加MACE的发生风险[1， 2]。抗血小板治疗是预防心血管疾病和血栓事件发生的重要手段， 受到个体差异影响， 不同个体对抗血小板药物治疗的反应存在差异， 在接受抗血小板药物治疗仍会发生血栓事件， 即“血小板抵, http://www.100md.com(梁华桂)
【关键词】 阿司匹林抵抗;2型糖尿病;不良心血管事件;冠心病
DOI：10.14163/j.cnki.11-5547/r.2018.12.002
【Abstract】 Objective To investigate the relationship between aspirin resistance (AR) and main adverse cardiovascular events (MACE) in patients with type 2 diabetes mellitus complicated with coronary heart disease. Methods A total of 120 patients with type 2 diabetes mellitus complicated with coronary heart disease were divided by occurrence of AR into AR group and non-AR group. The occurrence of MACE in the two groups was compared， and the patients were divided by occurrence of MACE into the occurrence group and non-occurrence group. The general data of patients was compared， and then the relationship between AR and MACE in patients with coronary heart disease and type 2 diabetes mellitus was analyzed. Results AR group had obviously higher incidence of MACE as 51.43% than 23.53% in non-AR group， and the difference was statistically significant (P<0.05). The occurrence group had no statistically significant difference in gender， systolic blood pressure， diastolic blood pressure， total cholesterol (TC)， high density lipoprotein cholesterol (HDL-C)， and fasting blood glucose (FBG) level， comparing with non-occurrence group (P>0.05). The occurrence group had statistically significant difference in age， body mass index (BMI)， triglyceride (TG)， low density lipoprotein cholesterol (LDL-C)， glycosylated hemoglobin (HbA1c) and AR occurrence， comparing with non-occurrence group (P<0.05). According to Logistic analysis， age， LDL-C， HbA1c and AR were factors affecting the occurrence of MACE (P<0.05). Conclusion There is a higher risk of MACE in patients with coronary heart disease and diabetes mellitus who have AR. Age， LDL-C， HbA1c and AR are all risk factors for the occurrence of MACE.
【Key words】 Aspirin resistance; Type 2 diabetes mellitus; Main adverse cardiovascular events; Coronary heart disease
多數冠心病患者合并有2型糖尿病， 二者常互为因果， 加重患者的病情， 增加MACE的发生风险[1， 2]。抗血小板治疗是预防心血管疾病和血栓事件发生的重要手段， 受到个体差异影响， 不同个体对抗血小板药物治疗的反应存在差异， 在接受抗血小板药物治疗仍会发生血栓事件， 即“血小板抵, http://www.100md.com(梁华桂)