分析孟鲁司特治疗支气管哮喘的临床效果及对肺功能和Th1、Treg平衡的调节作用(1)
【摘要】 目的 探究支氣管哮喘患者应用孟鲁司特治疗的临床效果和对肺功能、辅助T细胞(Th)1、调节性T细胞(Treg) 平衡的影响。方法 74例支气管哮喘患者， 按照入院先后时间分为实验组和对照组， 各37例。对照组行常规治疗， 实验组在对照组治疗的基础上行孟鲁司特治疗。观察比较两组治疗效果及治疗前后用力肺活量(FVC)、呼气峰值流速(PEF)、第1秒用力呼气容积(FEV1)、血清白细胞介素-10(IL-10)和干扰素-γ(IFN-γ)水平。结果 实验组患者总有效率91.89%显著高于对照组的72.97%， 差异有统计学意义(χ2=4.573， P=0.032<0.05)。治疗后， 实验组患者FVC、PEF和FEV1水平分别为(4.23±0.79)L、(8.44±1.22)L/s、(3.24±0.56)L， 显著优于对照组的(3.67±0.88)L、(7.68±0.99)L/s、(2.77±0.70)L， 差异有统计学意义(P<0.05)。治疗后， 实验组患者血清IL-10和IFN-γ水平分别为(3.11±0.54)、(3.98±0.41)ng/L， 显著优于对照组的(2.11±0.45)、(4.37±0.32)ng/L， 差异有统计学意义(P<0.05)。结论 支气管哮喘患者应用孟鲁司特治疗效果显著， 可有效稳定Th1、Treg水平， 并提升肺功能， 值得推广。
【关键词】 孟鲁司特;支气管哮喘;肺功能;辅助T细胞1;调节性T细胞
DOI：10.14163/j.cnki.11-5547/r.2019.01.047
【Abstract】 Objective To discuss the clinical effect of montelukast on patients with bronchial asthma and its influence on lung function and helper T cell (Th1) and regulatory T cell (Treg) balance. Methods A total of 74 patients with bronchial asthma were divided by admission order into experimental group and control group， with 37 cases in each group. The control group received conventional therapy， and the experimental group received montelukast on the basis of the control group. Observation and comparison were made on treatment effect， levels of forced vital capacity (FVC)， peak expiratory flow (PEF)， forced expiratory volume (FEV1)， interleukin-10 (IL-10) and interferon-γ (IFN-γ) before and after treatment between the two groups. Results The experimental group had significantly higher total effective rate as 91.89% than 72.97% in the control group， and the difference was statistically significant (χ2=4.573， P=0.032<0.05). After treatment， the experimental group had significantly better FVC， PEF and FEV1 respectively as (4.23±0.79) L， (8.44±1.22) L/s and (3.24±0.56) L than (3.67±0.88) L， (7.68±0.99) L/s and (2.77±0.70) L in the control group， and their difference was statistically significant (P<0.05). After treatment， the experimental group had serum IL-10 and IFN-γ level respectively as (3.11±0.54) and (3.98±0.41) ng/L， which was significantly better than (2.11±0.45) and (4.37±0.32) ng/L in the control group， and their difference was statistically significant (P<0.05). Conclusion The effect of montelukast on bronchial asthma patients is remarkable， and it can effectively stabilize Th1 and Treg levels and improve lung function. It is worth popularizing.
【Key words】 Montelukast; Bronchial asthma; Lung function; Helper T cell; Regulatory T cell, 百拇医药(朱庆)
【关键词】 孟鲁司特;支气管哮喘;肺功能;辅助T细胞1;调节性T细胞
DOI：10.14163/j.cnki.11-5547/r.2019.01.047
【Abstract】 Objective To discuss the clinical effect of montelukast on patients with bronchial asthma and its influence on lung function and helper T cell (Th1) and regulatory T cell (Treg) balance. Methods A total of 74 patients with bronchial asthma were divided by admission order into experimental group and control group， with 37 cases in each group. The control group received conventional therapy， and the experimental group received montelukast on the basis of the control group. Observation and comparison were made on treatment effect， levels of forced vital capacity (FVC)， peak expiratory flow (PEF)， forced expiratory volume (FEV1)， interleukin-10 (IL-10) and interferon-γ (IFN-γ) before and after treatment between the two groups. Results The experimental group had significantly higher total effective rate as 91.89% than 72.97% in the control group， and the difference was statistically significant (χ2=4.573， P=0.032<0.05). After treatment， the experimental group had significantly better FVC， PEF and FEV1 respectively as (4.23±0.79) L， (8.44±1.22) L/s and (3.24±0.56) L than (3.67±0.88) L， (7.68±0.99) L/s and (2.77±0.70) L in the control group， and their difference was statistically significant (P<0.05). After treatment， the experimental group had serum IL-10 and IFN-γ level respectively as (3.11±0.54) and (3.98±0.41) ng/L， which was significantly better than (2.11±0.45) and (4.37±0.32) ng/L in the control group， and their difference was statistically significant (P<0.05). Conclusion The effect of montelukast on bronchial asthma patients is remarkable， and it can effectively stabilize Th1 and Treg levels and improve lung function. It is worth popularizing.
【Key words】 Montelukast; Bronchial asthma; Lung function; Helper T cell; Regulatory T cell, 百拇医药(朱庆)