14.95) nmol/(mg·prot) in SIR group. MDA level of IR and SIR group were higher than that of S group， and SOD activity was lower than that of S group; MDA level of SIR group was lower than that of IR group， and SOD activity was higher than that of IR group. The difference was statistically significant (P<0.05). Conclusion Sitagliptin can reduce the pathological changes of gastrocnemius in rats with ischemia-reperfusion injury ......