氟比洛芬酯预防气管内全麻患者术后躁动的临床观察(1)
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【摘要】 目的 探讨氟比洛芬酯超前镇痛预防气管内全麻患者术后躁动的有效性与安全性。方法 选择胸科手术60例患者,随机均分为两组,F组和T组,每组30例。分别在手术结束前30 min,F组静脉注射氟比洛芬酯100 mg,T组静脉注射盐酸曲马多100 mg。观察两组患者拔管时间、苏醒时间及术后躁动情况。结果 F组患者拔管时间、苏醒时间明显快过T组(P<0.05);F组患者术后躁动发生率明显少于T组、术后躁动程度也好过T组(P<0.01)。结论 氟比洛芬酯超前镇痛预防气管内插管全麻患者术后躁动有效且安全。
【关键词】氟比洛芬酯;超前镇痛;术后躁动;气管内;全麻
Observate of clinical flurbiprofen axetil on preventing postoperative restlessness of tracheal general anaesthesia
LI Zhi ping,LIN Yong feng,ZHANGg Shu.People’s Hospital of Dongguan,Guangdong 523018,China
【Abstract】 Objective To investigate the efficacy and safety of preemptive analgesia effect of flurbiprofen axetil on preventing postoperative restlessness.Methods 60 patients who receivedthoracic surgery were randomly assigned into two groups(F and T).The patients in group F(n=30)received intravenous injection of flurbiprofen axetil 100 mg 30 min before the ending of surgery,while group T received intravenous injection of tromadol hcl 100 mg.The time of extubationand awaken were recorded,the rates of postoperative restlessness and the grade 0~3 of restlessness were recorded too.Results The time of extubation and awaken in group F were shorter than that of group T(P<0.05); the rates of postoperative restlessness were decreased from 60%to 10%remarkably,the degrees of restlessness in group F were lower than thatin group T(P<0.01).Conclusion The preemptive analgesia effect of flurbiprofen axetil on preventing postoperative restlessness for tracheal general anaesthesia is effectual and safe.
【Key words】 Flurbiprofen axetil; Preemptive analgesia; Postoperative restlessness;Tracheal;General anesthesia
术后躁动是气管内全麻患者常见的并发症,强烈的术后躁动可引起意外伤害,甚至危及患者的生命。了解术后疼痛时引起躁动的重要因素,消除或减轻术后疼痛,就能有效地减少术后躁动的发生。本研究采用新型非甾体类靶向镇痛药氟比洛芬酯(Flurbiprfen Axetil)静脉注射,探讨氟比洛芬酯超前镇痛在预防气管插管全麻患者术后躁动的有效性与安全性。
1 资料与方法
1.1 病例选择与分组 随机选取择期ASAI~II级拟行肺癌根治术的患者60例,男32例、女28例,年龄45~65岁,所有患者均无心、脑、肝、肾及内分泌系统疾病史,无凝血功能障碍,无溃疡和异常出血史,术前24 h未使用非甾体类抗炎药或麻醉性镇痛药。将患者随机分为F、T 两组,每组30例,在手术结束前30 minF组静脉注射氟比洛芬酯100 mg,T组静脉注射盐酸曲马多100 mg。所有患者都是在气管插管全麻+硬膜外麻醉下进行手术。
1.2 麻醉方法 两组患者术前30 min均肌肉注射阿托品0.5 mg、鲁米那0.1 g。诱导:咪达唑仑0.05 mg/kg,芬太尼0.004 mg/kg,丙泊酚1 mg/kg,阿曲库铵1~1 ......
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