阿托伐他汀钙对慢性心力衰竭患者临床及血浆脑利钠肽水平的影响(1)
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【摘要】 目的 观察阿托伐他汀钙对慢性心力衰竭(CHF)患者临床及血浆脑利钠肽水平的影响。方法 110例CHF患者随机分为两组:对照组54例患者给予抗心力衰竭的常规治疗,如限盐、休息,根据病情选用利尿剂、血管紧张素转化酶抑制剂、β受体阻滞剂、螺内酯、硝酸酯类药物等,必要时根据病情应用洋地黄、多巴酚丁胺等正性肌力药物、抗生素。治疗组56例在对照组基础上加用阿托伐他汀钙20 mg,每晚餐时服用1次。两组均治疗6个月。结果 治疗6个月后治疗组总有效率显著高于对照组(P<0.05);治疗组LVEF较对照组增加更显著(P<0.01);治疗组血浆BNP水平较对照组下降更显著(P<0.01)。结论 CHF患者在常规治疗同时加用阿托伐他汀钙治疗,可以显著降低血浆BNP水平,增加LVEF,改善心功能。
【关键词】慢性心力衰竭;阿托伐他汀钙;脑利钠肽;左室射血分数
Effects of atorvastatin calcium on chronic heart failure and plasma brain natriuretic peptide levels
HAN Rong ping.Ward Cadres,The People’s Hospital of Jiaozuo City,Henan Province 454002,China
【Abstract】 Objective To observe the effects of atorvastatin calcium on chronic heart failure(CHF) and plasma brain natriuretic peptide levels.Methods 110 cases of CHF were randomly divided into two groups:control group(54 cases)of heart failure in patients received conventional treatment,such as salt restriction,rest,under the condition chosen diuretics,angiotensin converting enzyme inhibitors,β blocker,spironolactone,nitrates and other substances,if necessary,the application of digitalis like illness,stress and other positive inotropic drugs,antibiotics.Treatment group(56 cases)received atorvastatin calcium 20 mg based on the control group,take 1 before each dinner.Two groups were treated for 6 months.Results After 6 months,The efficiency of the treatment group was significantly higher than that of the control group(P<0.05); the LVEF of the treatment group increased significantly than that of the control group(P<0.01); The plasma BNP levels of the treatment group decreased significantly than the control group(P<0.01).Conclusion The patients of CHF can significantly reduce plasma BNP levels,increase LVEF,improve cardiac function at the same time in the conventional treatment plus atorvastatin calcium treatment.
【Key words】 Chronic heart failure; Atorvastatin calcium; Brain natriuretic peptide; Left ventricular ejection fraction
脑利钠肽(BNP)是由心室肌细胞分泌的神经激素,大量研究表明,BNP水平的高低可反映CHF的严重程度及预后,BNP对CHF的诊断、预后评估及疗效评定有非常重要的意义。随着研究的深入,发现他汀类药物具有除降血脂以外的心血管系统多效性作用。据此,笔者观察了阿托伐他汀钙对CHF患者临床及血浆BNP的影响,以评价其对心力衰竭患者心肌的保护作用 ......
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