【摘要】 目的 探讨骨髓增生异常综合征(MDS)高危患者的有效治疗方法。方法 笔者采用联合应用沙利度胺治疗高危MDS 15例。结果 在12例可评价的MDS病例中完全缓解4例(33.3%),部分缓解4例(33.3%),进步2例(16.7%),无效2例(16.7%)。毒副作用小。结论 沙利度胺联合治疗高危MDS有明显的疗效,且毒副作用小,值得扩大病例进一步研究及推广。

    【关键词】骨髓增生异常综合征;沙利度胺;高危

    An observation of combined therapy with thalidomide in high risk myelodysplastic syndrome

    ZHONG Ya ping,XU Chun ling,LIU Nong jun.Department of Hematology,the Centre Hospital of Zhumadian,Zhumadian 46300,China

    【Abstract】 Objective To investigate the efficacy in treating high risk myelodysplastic syndrome(MDS).Methods 15 cases of high risk MDS were treated by combined therapy with thalidomide.Results Except that 1 cases stopped using thalidomide for suffering from diabetic neuropathy and 2 for allergy.12 cases had been evaluated.4 cases achieved CR(33.3%),4 cases achieved PR(33.3%),2 got better(16.7%)and there were no effect on 2 patients(16.7%).Mild side and toxic effects were observed.Conclusion Combined Therapy with thalidomide has significant effect in high risk of MDS patients.There are mild side or toxic effects.But we need more cases to draw the conclusion. ......