川芎嗪关节腔内注射治疗膝关节骨性关节炎的临床观察(1)
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【摘要】 目的 探讨川芎嗪关节腔内注射治疗膝关节骨性关节的临床效果。方法 将60例膝关节骨性关节炎患者随机分成治疗组和对照组,每组30例。治疗组行关节镜下关节清理术并腔内注射川芎嗪;对照组关节镜下关节清理术并腔内注射透明质酸钠。采用日本整形协会(JOA)制定的评定标准,于术后1周、3个月、6个月、12个月做疗效评定;并检测术前、术后1、10、20 d血清C 反应蛋白(CRP)的含量。结果 术后1周两组无显著差异(P>0.05);术后3个月、6个月、12个月治疗组疗效明显优于对照组,差异非常显著(P<0.01);治疗组术后10 dCRP含量明显低于对照组,有非常显著差异(P<0.01)。结论 川芎嗪关节腔内注射是治疗膝关节骨性关节炎的有效方法。
【关键词】川芎嗪;膝关节骨性关节炎;C 反应蛋白
Injecting chuanqiongqin in treating knee osteoarthritis
DU Fang tao,MA Hong guang,SHANG Bo,et al.Department of Orthopaedics,the Affiliated Second People’s Hospital of Liaocheng of Shandong Taishan Medical College,Linqing 252600,China
【Abstract】 Objective To study the therapeutic effect of injecting chuanqiongqin in treating knee osteoarthritis.Methods 60 cases of knee osteoarthritis were divided into two groups randomly:treating group and control group,30 cases in a group.The treating group were treated by arthroscopic operation cooperated with injecting chuanqiongqin; the control group were given hyaluronate NA weeks after received knee bone arthritis.The operation evaluation criteria of JOA was taken to value the therapeutic effect at1 week,3 month,6 months and 12 months postoperation.At the same time,CRP(C reactive protein)content in serum were measured at preoperation,1 day,10 days,20 days postoperation.Results At 1 week postoperation,there were no apparent differences(P>0.05)between the 2 groups.at 3 month,6 months and 12 months postoperation,the therapeutic effect of the treating group was much better than that of the control group,there were significant differences(P<0.01)between the 2 groups; At 10 days postoperation,the serum CRP content in the treating group was much lower than that of the control group,there were significant differences(P<0.01)between the 2 groups.Conclusion Injecting chuanqiongqin in treating knee osteoarthritis should be valid methods in treating knee osteoarthritis.
【Key words】Chuanqiongqin; Knee bone arthritis; C reactive protein(CRP)
膝关节骨性关节炎(0A)的诊断标准主要根据美国风湿学会(ACR)的标准:中老 年患者,发病年龄40~70岁;以膝关节疼痛为第一 主诉,兼有晨僵、酸软、跛行、上下楼梯或斜坡行走困 难等症状;可有轻度关节肿胀、肥大或少许积液;可听到或扪及关节磨擦音,关节活动受限;实验检查抗 “0”,血沉、类风湿因子均属于正常[1] ......
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