六种治疗原发性高血压药物的成本 效果分析(1)
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【摘要】 目的 探讨六种口服给药治疗原发性高血压的成本 效果。方法 将158例患者分为A、B、C、D、E、F六组,A组给予杭州赛诺菲安万特民生制药有限公司生产的厄贝沙坦片(商品名:安博维,150 mg),B组给予勃林格殷格翰药业有限公司生产的替米沙坦片(商品名:美卡素,80 mg),C组给予华夏药业集团有限公司生产的盐酸贝尼地平片(商品名:元治,4 mg),D组给予杭州默沙东制药有限公司生产的氯沙坦钾片(商品名:科素亚,50 mg),E组给予威海迪沙药业集团有限公司生产的坎地沙坦酯片(商品名:迪之雅,8 mg),F组给予口服北京诺华制药有限公司生产的缬沙坦胶囊(商品名:代文,80 mg),以药物经济学的成本 效果分析(CEA)六种方案。结果 A、B、C、D、E、F方案的有效率相差不大,但B方案好一些,六种方案的成本 效果比分别为2.73、2.86、1.80、3.54、1.98、3.30,敏感度分析成本 效果比分别为2.45、2.57、1.69、3.19、1.78、2.97。结论 B方案在六种方案中最佳。
【关键词】厄贝沙坦片;替米沙坦片;盐酸贝尼地平片;氯沙坦钾片;坎地沙坦酯片;缬沙坦胶囊;原发性高血压
Analyses on the cost of six drugs for trearment essential Hypertension
YU Yong,WANG Xi ping,ZHANG Li na,et al. Shandong Weihai Shili hospital,Weihai Dental hospital,Weihai 264200,China
【Abstract】 Objective To investigate the trearment cost of essential hypertension in Oral Drug Administration.Methods One hundred fifty eight aegras were randomly divided into six groups.numeration were A,B,C,D,E,F.Group A received Irbesartan Tablets produced by Sanofi Winthrop Industrie,France.Group B received Telmisartan Tablets produced by Boehringer Lngelheim.Group C received Benidipine Hydrochloride Tablets produced by Huaxia Pharmaceutical Group Company.Group D received losartan potassium tablets produced by E.I.Du pont de Nemours and Company Wilmington.Delaware,USA.Group E received Canddesartan Cilexetil Tablets produced by Disha Pharmaceutical Group Company.Group F received Valsartan Capsules produced by Beijing Novartis pharma Ltd.Analyze the six programs in cost of Pharmacoeconomics.Results In the study,there was less difference in the six groups,unless group B was little better.The ratio of treatment cost was 2.73,2.86,1.80,3.54,1.98,3.30 in the different six groups respectively .Cost sensitivity analysis is 2.45,2.57,1.69,3.19,1.78,2.97 in the different six groups respectively .Conclusion The program for group B is the best.
【Key words】Irbesartan Tablets; Telmisartan Tablets; Benidipine Hydrochloride Tablets; Losartan Potassium Tablets; Canddesartan Cilexetil Tablets; Valsartan Capsules; Essential Hypertension
原发性高血压是以环境因素为主,由遗传因素和环境因素综合作用而引起的一种慢性疾病。常引起严重的心、脑、肾并发症,是脑卒中、冠心病的主要危险因素。而且高血压患病率有上升趋势,我国目前高血压总患病率为11.88%[1]。因此利用药物经济学的分析方法对合理使用高血压药物有着重要的意义。
1 资料与方法
1.1 临床资料 原发性高血压患者158例均为门诊患者,其中男性85例,女性73例。年龄35~65岁。平均50岁。排除继发性高血压,心、脑、肾严重并发症,严重烟、酒嗜好,药物成瘾、孕妇、哺乳期妇女,以及对所服用的降压药物有过敏史者等。各组患者在体重、基础血压及心率方面差异无统计学意义,具有可比性(P>0 ......
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