血清肿瘤标志物CA125\CA199\CEA\NSE联合检测在肺癌诊断中的应用(1)
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【摘要】 目的 探讨血清肿瘤标志物CA125、CA199、CEA、NSE联合检测在肺癌诊断中的应用价值。方法 选择本院2009年1月至2010年2月住院的肺癌患者220例肺癌病例组,选取同期我院健康体检人员为正常对照组250例,进行肿瘤标志物CA125、CA199、CEA、NSE进行联合检测。结果 经统计学分析肺癌病例组CA125、CEA、NSE血清水平明显高于正常对照组,差异有显著性意义(P<0.01),CA199在两组的表达水平比较无显著性差异(P>0.05)。经统计学分析CA125、CEA、NSE与联合检测三项肿瘤标志物之间的敏感性、特异性比较有显著型差异(P<0.01)。结论 单项肿瘤标志物检测,可以对临床有一定的指导性,但在敏感性、特异性均方面各有欠缺,很多肿瘤标志物与其他相应的疾病有一定的交叉性,对单项肿瘤标志物检测指导临床诊断价值有限,同时选用多项肿瘤标志物进行检测,可以达到单项检测在敏感性和特异性上的不足,能够有效的为临床提供有价值的佐证资料,以能够达到初筛和早期诊断的目的。
【关键词】肺癌;血清肿瘤标志物;应用价值
Serum tumor marker CA125,CA199,CEA,NSE combined detection of lung cancer diagnosis
WANG Feng.
The first people’s hospital of Shanqiu Henan,Shanqiu 476100,China
【Abstract】 Objective To explore the serum tumor marker CA125,CA199,CEA,NSE combined detection in the diagnosis of lung cancer in the application.Methods The hospital in January 2009-2010 year in February hospitalized patients with lung cancer group of 220 cases of lung cancer cases,select the same period the health physical examination in our hospital staff to the normal control group of 250 patients for tumor markers CA125,CA199,CEA,NSE to conduct joint detection.Results After statistical analysis of lung cancer cases group of CA125,CEA,NSE serum levels were significantly higher than the normal control group,the difference was significant(P<0.01),CA199 expression levels in the two groups showed no significant difference(P>0.05).The statistical analysis of CA125,CEA,NSE and the combined detection of three tumor markers between the sensitivity,specificity,and there was significant difference between type(P<0.01).Conclusion The single tumor markers,you can have some clinical guidance,but in sensitivity,specificity,have their own lack of both,many tumor markers and other relevant diseases have a certain cross-cutting nature of the individual tumor markers testing to guide clinical diagnosis of limited value,while a number of tumor markers selected for testing,and they can detect single on the lack of sensitivity and specificity,can effectively provide valuable support for clinical information in order to achieve the early The purpose of screening and early diagnosis ......
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