尖锐湿疣患者治疗前后血清hs-CRP和抵抗素检测的临床意义(1)
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【摘要】 目的 探讨了尖锐湿疣患者治疗前后血清hs-CRP和抵抗素水平的变化及意义。方法 采用酶联免疫(ELISA)法检测血清抵抗素含量,采用免疫比浊法对血清Hs-CRP进行测定;分别对62例尖锐湿疣患者进行了血清hs-CRP和抵抗素检测,并与35名正常健康人作比较。结果 在治疗前尖锐湿疣患者hs-CRP和抵抗素水平均非常显著地高于正常人组(P<0.01)。经3个月治疗后血清hs-CRP和抵抗素水平与正常人组比较无显著性差异(P>0.05)。患者组治疗前后血清hs-CRP和抵抗素水平也有显著性差异(P<0.01)。尖锐湿疣患者患者抵抗素浓度与Hs-CRP浓度呈正相关(r=0.73,P<0.01)。结论 检测尖锐湿疣患者血清hs-CRP和抵抗素水平的变化对疾病的治疗、预后观察有重要的临床价值。
【关键词】尖锐湿疣;超敏C反应蛋白;抵抗素
Clinical significance of determination of changes hs-CRP and resistin levels after treatmentin patients with condyloma Acuminatum
YAN Xu,ZHOU Yong-qin,HUANG You-min.The Central People’s Hospital of Tengzhou,Shandong277500,China
【Abstract】 Objective To explore the significance of changes of serum high sensitive C reactive protein(hs-CRP) and resistin levels after treatment in patients with condyloma acuminatum.Methods The concentrations of resistin was measured by enzyme-linked immunosorbent assay(ELISA),and Hs-CRP was determined by rate nephelometry immunoassay and be measured both before and after treatment in 62 patients with condyloma acuminatum and 35 conrols.Results Before treatment,the serum hs-CRP and resistin levels in the patients were significantly higher than those in controls(P<0.01).After treatment for 3 months,the levels were not significantly different from those in controls(P>0.5).Serum hs-CRP and resistin lends in patients before the treatment were significantly higher than those after treatent(P<0.01).There was positive correlation between the concentrations of resistin and hs-CRP in patients with condyloma acuminatum(r=0.73,P<0.01).Conclusion The levels of serum hs-CRP and resistin increased significantly in patients with condyoma acuminatum especially in those advanced cases had important significance.
【Key words】Condyloma acuminatum;High sensitive C reactive protein(hs-CRP);Resistin
DOI:10.3760/cma.j.issn 1673-8799.2010.06.39
作者单位:277500 山东省滕州市中心人民医院皮肤科(严旭 周永勤),输血科(黄友敏)
尖锐湿疣又称尖圭湿疣,是由人类乳头瘤病毒(HPV)感染所引起的一种常见的性传播疾病,主要通过性接触传播的疾病。抵抗素是近年发现的脂肪细胞因子,和炎症反应密切相关;hs-CRP为急性时相蛋白[1]。笔者通过检测尖锐湿疣患者治疗前后血清hs-CRP和抵抗素含量的变化,探讨其在尖锐湿疣患者治疗前后血清中的变化特点 ......
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