新疆100例HIV/AIDS患者机体细胞免疫与合并机会性感染关系的研究(1)
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【摘要】 目的 探讨人类免疫缺陷病毒(HIV)感染者和艾滋病(AIDS)患者机体细胞免疫与合并机会性感染的关系。方法 总结新疆100例HIV/AIDS患者临床资料,分析CD+3、CD+4、CD+8细胞水平,及CD+4细胞数与发生机会性感染的关系。结果 HIV/AIDS 患者合并机会感染CD+3、CD+4细胞数明显低于未合并机会感染组且差异均具有统计学意义(t=-2.073,t=-4.087,P<0.05),CD+8、CD+4/CD+8比值则差异无统计学意义(P>0.05)。CD+3细胞数与CD+4细胞数的变化呈正相关(r=0.481,P<0.05),与CD+8细胞数的变化呈高度正相关(r=0.954,P<0.05)。CD+4细胞含量<200个/μl时,发生机会性感染高于CD+4 细胞含量为200~500个/μl时,且差异有统计学意义(χ2=17.27 2,P<0.05)。在CD+4细胞含量<200个/μl的HIV/AIDS 患者中以PCP的合并感染为最高27.27%,其次弓形虫和结核(22.73%,13.64%)。结论 HIV/AIDS患者并发机会性感染与免疫抑制程度有关,CD+4的水平是目前监测机会性感染的重要参考依据,不同地区机会性感染疾病谱略有不同,临床可采取相应的预防性治疗措施。
【关键词】 人类免疫缺陷病毒;获得性免疫缺陷综合征;细胞免疫;机会性感染
Analysis of the relationship between cytoimmunity and the complication of opportunistic infection in 100 HIV/AIDS patients of Xinjiang
PANG Xiu-hui, MO Hong-mei.Department of Laboratory Medicine,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China
【Abstract】 Objective To investigate the relationship between cytoimmunity and opportunistic infection complicated in HIV/AIDS patients.Methods The level of CD+3,CD+4,CD+8 T cells and opportunistic infection were analyzed in 100 HIV/AIDS patients in Xinjiang.Results The level of CD+3 and CD+4 T cells in AIDS companized with opportunistic infection was lower than those without opportunistic infection.The difference between these two groups was significant(t=-2.073,t=-4.087,P<0.05),but no significance on CD+8 T cells and CD+4/CD+8(P>0.05).Significant positive correlation was observed between CD+3 and CD+4 T cells(r=0.481,P<0.05),either between CD+3 and CD+8 T cells(r=0.954,P<0.05).The incidence of opportunistic infection in AIDS patients with CD+4T cells count<200/μl was higher than those with 200-500/μl CD+4T cells,and the difference was significant(χ2=17.27 2,P<0.05).The incidence of PCP(27.27%)was the highest,then was toxoplasma(22.73%)and TB(13.64%)was the third one in opportunistic infection in AIDS patients with CD+4T cells count<200/μl ......
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